ASCs-derived exosomes loaded with vitamin A and quercetin inhibit rapid senescence-like response after acute liver injury
ASCs-derived exosomes loaded with vitamin A and quercetin inhibit rapid senescence-like response after acute liver injury
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DOI：
10.1016/j.bbrc.2021.07.059
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发表时间：
2021-08-04
影响因子：
3.1
通讯作者：
Liang, Wulong
中科院分区：
文献类型：
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作者：
Fang, Jia;Liang, Wulong
急性肝损伤是一种短期的突发性肝细胞损伤，其原因多，机制复杂。尽管肝脏具有独特的自我修复能力，但对于急性肝损伤引起的慢性肝损伤甚至肝功能衰竭，目前除了肝移植外，还没有其他有效的治疗方法。干细胞来源的外切体具有独特的免疫调节作用和结构特点，是理想的药物载体。本研究构建了负载槲皮素和维生素A的脂肪间充质干细胞(ASCs)外切体，并将其用于治疗CCl4诱导的小鼠急性肝损伤。槲皮素可增强外切体的治疗效果，而维生素A可增强外切体的肝脏靶向性，研究发现，负载槲皮素和维生素A的间充质干细胞外切体可降低急性肝损伤引起的快速衰老样反应。(C)2021 Elsevier Inc.保留所有权利。
Acute liver injury is a short-term burst of liver cell damage, which has many causes and complex mechanisms. Despite the unique ability of the liver to heal itself, there is still no effective treatment except liver transplantation for chronic liver injury or even liver failure caused by acute liver injury. Stem cell-derived exosomes are ideal drug carriers due to their unique immunomodulatory effects and structural characteristics. In this study, quercetin and vitamin A loaded adipose mesenchymal stem cells (ASCs)-derived exosomes were constructed and used to treat acute liver injury induced by CCl4 in mice. Quercetin enhances the therapeutic efficacy of exosomes, while vitamin A enhances the liver targeting of exosomes, and it was found that quercetin and vitamin A loaded mesenchymal stem cell exosomes reduce rapid senescence-like response induced by acute liver injury. (c) 2021 Elsevier Inc. All rights reserved.