CLONING AND SEQUENCE-ANALYSIS OF CDNA-ENCODING THE PRECURSOR OF A HUMAN ENDOTHELIUM-DERIVED VASOCONSTRICTOR PEPTIDE, ENDOTHELIN - IDENTITY OF HUMAN AND PORCINE ENDOTHELIN
CLONING AND SEQUENCE-ANALYSIS OF CDNA-ENCODING THE PRECURSOR OF A HUMAN ENDOTHELIUM-DERIVED VASOCONSTRICTOR PEPTIDE, ENDOTHELIN - IDENTITY OF HUMAN AND PORCINE ENDOTHELIN
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DOI：
10.1016/0014-5793(88)80867-6
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发表时间：
1988-04-25
期刊：
影响因子：
3.5
通讯作者：
MASAKI, T
中科院分区：
文献类型：
--
作者：
ITOH, Y;YANAGISAWA, M;MASAKI, T
从人胎盘 cDNA 文库中分离出编码人内皮源性血管收缩肽（内皮素）的 cDNA。该cDNA克隆的核苷酸序列表明，人前内皮素原的一级结构有212个氨基酸残基，与猪前内皮素原高度同源，人内皮素与猪内皮素相同。
A cDNA encoding a human endothelium‐derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.