Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats
Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats
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DOI：
10.1037/0735-7044.116.4.553
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发表时间：
2002-08-01
影响因子：
1.9
通讯作者：
Everitt, BJ
中科院分区：
文献类型：
--
作者：
Cardinal, RN;Parkinson, JA;Everitt, BJ
杏仁核核心（AcbC）、前扣带皮层（ACC）和杏仁核中央核（CeA）是基于刺激-奖励关联的正常任务获取所必需的。然而，目前尚不清楚它们是否纯粹参与学习过程，或者是学习反应的行为表达所必需的。在巴甫洛夫自动成形任务中，将视觉条件刺激（CS+）与食物配对会导致受试者接近CS+，而不是接近未配对的刺激（CS-）。然后，受试者在重新测试之前接受AcbC、ACC或CeA的损伤。AcbC病变严重损害性能;病变受试者接近CS+的频率显着低于对照组，未能区分CS+和CS-。ACC病变也损害了性能，但并没有完全消除歧视。CeA病变对性能没有影响。因此，CeA是学习所需的，但不是表达，条件接近反应，这意味着它使一个特定的贡献，学习刺激奖励协会。
The nucleus accumbens core (AcbC), anterior cingulate cortex (ACC), and central nucleus of the amygdala (CeA) are required for normal acquisition of tasks based on stimulus-reward associations. However, it is not known whether they are involved purely in the learning process or are required for behavioral expression of a learned response. Rats were trained preoperatively on a Pavlovian autoshaping task in which pairing a visual conditioned stimulus (CS+) with food causes subjects to approach the CS+ while not approaching an unpaired stimulus (CS-). Subjects then received lesions of the AcbC, ACC, or CeA before being retested. AcbC lesions severely impaired performance; lesioned subjects approached the CS+ significantly less often than controls, failing to discriminate between the CS+ and CS-. ACC lesions also impaired performance but did not abolish discrimination entirely. CeA lesions had no effect on performance. Thus, the CeA is required for learning, but not expression, of a conditioned approach response, implying that it makes a specific contribution to the learning of stimulus-reward associations.