The contractile response of the uterus to cocaine.
The contractile response of the uterus to cocaine.
复制标题
子宫对可卡因的收缩反应。
DOI：
--
复制
发表时间：
1966
影响因子：
2.1
通讯作者：
M. Wolowyk
中科院分区：
文献类型：
--
作者：
E. Daniel;M. Wolowyk
对古柯碱致兔子宫节段挛缩进行了分析。其他局麻药也能产生类似的反应，但产生挛缩的效力与产生局麻药的效力无关。挛缩不是由内源性儿茶酚胺增强或与α-肾上腺素能受体或催产素受体刺激有关的任何机制引起的。血清素和乙酰胆碱受体也没有参与。子宫肌细胞去极化防止可卡因引起的挛缩。它们是钙依赖性的，在无钙培养基中比对乙酰胆碱或去甲肾上腺素的反应消失得更快。锶和钙均能恢复，但比乙酰胆碱反应慢。有人提出，可卡因引起松散结合在兔子宫段膜上的钙的不稳定，从而导致子宫挛缩。
Cocaine-induced contractures of rabbit uterine segments were analyzed. Similar responses were produced by other local anesthetics, but potency in producing contractures was unrelated to that in producing local anesthesia. Contractures were not produced by potentiation of endogenous catecholamines or by any mechanism related to stimulation of α-adrenergic receptors or oxytocin receptors. Receptors for serotonin and acetylcholine were also not involved. Depolarization of the uterine muscle cells prevented cocaine-induced contractures. They were calcium-dependent and disappeared more rapidly than responses to acetylcholine or noradrenaline in a calcium-free medium. They were restored both by strontium and by calcium, but more slowly than were acetylcholine responses. It is proposed that cocaine causes labilization of calcium loosely bound in the membrane in rabbit uterine segments and that this leads to contracture.