Learning about pain: The neural substrate of the prediction error for aversive events
Learning about pain: The neural substrate of the prediction error for aversive events
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DOI：
10.1073/pnas.160266497
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发表时间：
2000-08-01
影响因子：
11.1
通讯作者：
Matthews, PM
中科院分区：
文献类型：
--
作者：
Ploghaus, A;Tracey, I;Matthews, PM
联想学习被认为依赖于检测实际经验和预期经验之间的不匹配。利用功能磁共振成像(FMRI)，我们研究了不同类型不匹配时的大脑活动，在一个范式中，对比色光表示传递疼痛的热、非疼痛的温暖或没有刺激，当疼痛的热刺激是意想不到的时，海马区、额上回、小脑和顶上回的fMRI信号强度增加，但预期和非疼痛温暖刺激的传递之间没有发现不匹配的情况。当疼痛的热刺激被意外忽略时，左侧顶上回的fMRI信号强度降低，其他区域的信号强度增加。这些不同的激活模式对应于联想学习理论中的两个不同的不匹配概念(Rescorla-Wagner，Temporal Difference vs，Pearce-Hall，Mackintosh)，因此，寻找干预措施来专门调节这些大脑区域的激活，从而为确定慢性疼痛的新治疗方法提供了一种方法，慢性疼痛通常具有实质性的联想学习成分。
Associative learning is thought to depend on detecting mismatches between actual and expected experiences. With functional magnetic resonance imaging (FMRI), we studied brain activity during different types of mismatch in a paradigm where contrasting-colored lights signaled the delivery of painful heat, nonpainful warmth, or no stimulation, When painful heat stimulation was unexpected, there was increased FMRI signal intensity in areas of the hippocampus, superior frontal gyrus, cerebellum, and superior parietal gyrus that was not found with mismatch between expectation and delivery of nonpainful warmth stimulation. When painful heat stimulation was unexpectedly omitted, the FMRI signal intensity decreased in the left superior parietal gyrus and increased in the other regions. These contrasting activation patterns correspond to two different mismatch concepts in theories of associative learning (Rescorla-Wagner, temporal difference vs, Pearce-Hall, Mackintosh), Searching for interventions to specifically modulate activation of these brain regions therefore offers an approach to identifying new treatments for chronic pain, which often has a substantial associative learning component.