EEG sigma and slow-wave activity during NREM sleep correlate with overnight declarative and procedural memory consolidation
EEG sigma and slow-wave activity during NREM sleep correlate with overnight declarative and procedural memory consolidation
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DOI：
10.1111/j.1365-2869.2012.01017.x
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发表时间：
2012-12-01
影响因子：
4.4
通讯作者：
Nissen, Christoph
中科院分区：
文献类型：
--
作者：
Holz, Johannes;Piosczyk, Hannah;Nissen, Christoph
先前的研究表明，睡眠特定的大脑活动模式，如睡眠纺锤波和脑电图慢波活动，有助于巩固新记忆。睡眠纺锤波和慢波活动的产生都依赖于丘脑-皮层网络的同步振荡，这可能与睡眠期间突触的强化（纺锤波）和缩减（慢波活动）有关。本研究进一步研究了20名健康受试者（10名男性，27.1±4.6岁）非快速眼动睡眠时纺锤波（sigma, 1216 Hz）和慢波频率范围（0.13.5 Hz）的脑电图功率与夜间记忆巩固之间的关系。我们发现脑电图的西格玛功率和慢波活动都与睡眠前陈述性记忆（单词列表）和程序性记忆（镜像追踪）的巩固呈正相关。这些结果，虽然在本质上只是相关的，但与突触强化（睡眠纺锤波）和突触缩小（慢波活动）的过程可能协同作用，促进突触可塑性和睡眠期间陈述性和程序性记忆的巩固的观点是一致的。
Previous studies suggest that sleep-specific brain activity patterns such as sleep spindles and electroencephalographic slow-wave activity contribute to the consolidation of novel memories. The generation of both sleep spindles and slow-wave activity relies on synchronized oscillations in a thalamo-cortical network that might be implicated in synaptic strengthening (spindles) and downscaling (slow-wave activity) during sleep. This study further examined the association between electroencephalographic power during non-rapid eye movement sleep in the spindle (sigma, 1216 Hz) and slow-wave frequency range (0.13.5 Hz) and overnight memory consolidation in 20 healthy subjects (10 men, 27.1 +/- 4.6 years). We found that both electroencephalographic sigma power and slow-wave activity were positively correlated with the prepost-sleep consolidation of declarative (word list) and procedural (mirror-tracing) memories. These results, although only correlative in nature, are consistent with the view that processes of synaptic strengthening (sleep spindles) and synaptic downscaling (slow-wave activity) might act in concert to promote synaptic plasticity and the consolidation of both declarative and procedural memories during sleep.