CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
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DOI：
10.1182/blood-2012-03-416867
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发表时间：
2012-10-25
期刊：
影响因子：
20.3
通讯作者：
Malmberg, Karl-Johan
中科院分区：
文献类型：
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作者：
Bjorkstrom, Niklas K.;Beziat, Vivien;Malmberg, Karl-Johan
杀伤细胞免疫球蛋白样受体（KIR）和它们的同源HLA I类配体之间的上位相互作用对生殖成功、抗病毒免疫、自身免疫性疾病和癌症的易感性以及异基因干细胞移植中的移植物抗白血病反应具有重要意义。尽管已知CD 8 T细胞在从幼稚细胞成熟为终末分化细胞时获得KIR，但关于人CD 8 T细胞上KIR库的构成的信息很少。在这里，我们对CD 8 T细胞上的KIR表达进行了高分辨率分析。结果表明，大多数CD 8 T细胞具有受限的KIR表达模式，通常由单一活化或抑制性KIR主导。此外，KIR的表达及其对CD 8 T细胞功能的调节不依赖于自身HLA I类配体的表达。最后，尽管双向近端启动子对KIR的随机调节具有相似性，但抑制性KIR对CD 8 T细胞的特异性通常与同一个体中自然杀伤细胞的特异性不同。这些结果为人类T细胞上KIR库的形成提供了新的见解。（血。2012;120（17）：3455-3465）
Epistatic interactions between killer cell immunoglobulin-like receptors (KIRs) and their cognate HLA class I ligands have important implications for reproductive success, antiviral immunity, susceptibility to autoimmune conditions and cancer, as well as for graft-versus-leukemia reactions in settings of allogeneic stem cell transplantation. Although CD8 T cells are known to acquire KIRs when maturing from naive to terminally differentiated cells, little information is available about the constitution of KIR repertoires on human CD8 T cells. Here, we have performed a high-resolution analysis of KIR expression on CD8 T cells. The results show that most CD8 T cells possess a restricted KIR expression pattern, often dominated by a single activating or inhibitory KIR. Furthermore, the expression of KIR, and its modulation of CD8 T-cell function, was independent of expression of self-HLA class I ligands. Finally, despite similarities in the stochastic regulation of KIRs by the bidirectional proximal promoter, the specificity of inhibitory KIRs on CD8 T cells was often distinct from that of natural killer cells in the same individual. The results provide new insight into the formation of KIR repertoires on human T cells. (Blood. 2012;120(17):3455-3465)