ESSENTIAL ROLE OF ADENOSINE, ADENOSINE-A1-RECEPTORS, AND ATP-SENSITIVE K+ CHANNELS IN CEREBRAL ISCHEMIC PRECONDITIONING
ESSENTIAL ROLE OF ADENOSINE, ADENOSINE-A1-RECEPTORS, AND ATP-SENSITIVE K+ CHANNELS IN CEREBRAL ISCHEMIC PRECONDITIONING
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DOI：
10.1073/pnas.92.10.4666
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发表时间：
1995-05-09
影响因子：
11.1
通讯作者：
LAZDUNSKI, M
中科院分区：
文献类型：
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作者：
HEURTEAUX, C;LAURITZEN, I;LAZDUNSKI, M
亚致死性缺血预处理可保护海马神经元免受随后致死性缺血损伤后的神经元损伤。使用腺苷A1受体激动剂和拮抗剂以及ATP敏感性K+通道开放剂和阻断剂的药理学方法已与神经元死亡和谷氨酸和γ-氨基丁酸受体亚单位、HSP 70、c-fos、c-jun、这表明缺血耐受的机制涉及一系列事件，包括腺苷的释放，腺苷A1受体的刺激，以及通过这些受体，磺酰脲敏感的ATP敏感的K+通道的开放。
Preconditioning with sublethal ischemia protects against neuronal damage after subsequent lethal ischemic insults in hippocampal neurons, A pharmacological approach using agonists and antagonists at the adenosine A1 receptor as well as openers and blockers of ATP-sensitive K+ channels has been combined with an analysis of neuronal death and gene expression of subunits of glutamate and gamma-aminobutyric acid receptors, HSP70, c-fos, c-jun, and growth factors, It indicates that the mechanism of ischemic tolerance involves a cascade of events including liberation of adenosine, stimulation of adenosine A1 receptors, and, via these receptors, opening of sulfonylurea-sensitive ATP-sensitive K+ channels.