Selective gamma-g globulin deficiencies in patients with recurrent pyogenic infections.
Selective gamma-g globulin deficiencies in patients with recurrent pyogenic infections.
复制标题
反复化脓性感染患者的选择性 γ-g 球蛋白缺乏。
DOI：
10.1056/nejm197009172831205
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
F. Rosen
中科院分区：
文献类型：
--
作者：
P. Schur;H. Borel;E. Gelfand;C. Alper;F. Rosen
本文报告了三名终生易患化脓性感染和进行性肺病的病人，发现他们的γG球蛋白有选择性缺陷。第1例患者的血清含有异常低浓度的γG1、γG2和γG4;第2例患者的血清缺乏γG1、γG2和γG3，第3例患者缺乏γG1和γG2。其他免疫球蛋白的血清浓度正常或升高。这些异常都不能被证明有遗传基础。丙种球蛋白替代治疗可防止这些患者感染复发。
Abstract Three patients with lifelong susceptibility to pyogenic infections and progressive pulmonary disease were found to have selective deficiencies in their γG globulins. The serum of the first patient contained abnormally low concentrations of γG1, γG2 and γG4; the serum of the second patient was deficient in γG1, γG2 and γG3, and the third patient lacked γG1 and γG2. The serum concentrations of the other immunoglobulins were either normal or elevated. None of these abnormalities could be shown to have a genetic basis. Gamma-globulin replacement therapy prevented recurrence of infection in these patients.