Tyrosine hydroxylase immunoreactive structures in the aged human olfactory bulb and olfactory peduncle
Tyrosine hydroxylase immunoreactive structures in the aged human olfactory bulb and olfactory peduncle
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DOI：
10.1016/s0891-0618(99)00035-6
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发表时间：
1999-11-01
影响因子：
2.8
通讯作者：
Huisman, E
中科院分区：
文献类型：
--
作者：
Hoogland, PV;Huisman, E
利用酪氨酸羟化酶单克隆抗体研究了正常人、老年人嗅球和嗅柄中多巴胺能结构的解剖分布。嗅球中存在三种不同的含有酪氨酸羟化酶的细胞群：(1)肾小球内部和周围的一组圆形、中等大小的细胞；(2)外网状层细胞；(3)分散在地层相册中的细胞。偶见颗粒细胞层中有少量标记神经元。在嗅柄中，有一些标记细胞存在于耻骨下方的浅层。含有酪氨酸羟化酶的终末样结构存在于肾小球层和外网状层。在少数情况下，在构成前嗅核的细胞群中也观察到密集的末端标记。嗅柄内可见散在的标记纤维。此外，本研究清楚地表明，个别情况之间存在数量差异，对此无法找到解释。(C) 1999 Elsevier Science B.V.版权所有
We studied the anatomical distribution of dopaminergic structures in the normal, aged, human olfactory bulb and olfactory peduncle with a monoclonal antibody against tyrosine hydroxylase. Three different tyrosine hydroxylase containing cell groups are present in the olfactory bulbs: (1) a group of round, medium-sized cells within and around the glomeruli; (2) cells in the external plexiform layer; and (3) cells that are scattered in the stratum album. Occasionally, a few labeled neurons can be observed in the granule cell layer. In the olfactory peduncle a few labeled cells are present in the superficial layers just underneath the pia. Tyrosine hydroxylase containing terminal-like structures are present in the glomerular layer and the external plexiform layer. In a few cases dense terminal labeling is also observed in the cell groups that constitute the anterior olfactory nucleus. In the olfactory peduncle scattered labeled fibers are present. In addition, the present study makes clear that quantitative differences exist between the individual cases for which no explanation could be found. (C) 1999 Elsevier Science B.V. All rights reserved.