Anti-oxidant mechanisms of kolaviron: Studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats
Anti-oxidant mechanisms of kolaviron: Studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats
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DOI：
10.1111/j.0305-1870.2005.04248.x
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发表时间：
2005-08-01
影响因子：
2.9
通讯作者：
Nwaokeafor, IA
中科院分区：
文献类型：
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作者：
Farombi, EO;Nwaokeafor, IA
1.在本研究中，我们研究了藤黄籽中的天然双黄酮可拉韦隆在体外和体外对大鼠血清脂蛋白氧化修饰敏感性的影响。此外，还研究了其对金属离子的螯合能力和减轻铁/抗坏血酸引起的微粒体脂质损伤的能力。服用科拉韦隆(100 mg/kg)7天的大鼠脂蛋白对铜诱导氧化的抵抗力显著提高，表现为滞后时间显著延长。显著(P
1. In the present study, we have examined the ability of kolaviron, a natural biflavonoid from Garcinia kola seeds, to prevent the susceptibility of rat serum lipoprotein to undergo oxidative modification in vitro and ex vivo. In addition, its ability to chelate metal ions and mitigate iron/ascorbate-induced damage to microsomal lipids was investigated.2. Lipoprotein resistance to copper-induced oxidation was highly improved in rats treated with kolaviron (100 mg/kg) for 7 days, as demonstrated by a significant increase in lag time compared with control. A significant (P