Autism Symptoms Across Adulthood in Men with Fragile X Syndrome: A Cross-Sectional Analysis.
Autism Symptoms Across Adulthood in Men with Fragile X Syndrome: A Cross-Sectional Analysis.
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DOI：
10.1007/s10803-015-2513-7
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发表时间：
2015-11
影响因子：
3.9
通讯作者：
Bailey DB
中科院分区：
文献类型：
--
作者：
Hartley SL;Wheeler AC;Mailick MR;Raspa M;Mihaila I;Bishop E;Bailey DB
采用横断面分析方法，对281名患有脆性X染色体综合征（FXS）的成年男性进行ASD症状的年龄相关差异及相应的破坏性行为和社交技能差异的研究。分为18-21岁、22-29岁、30-39岁、40-49岁四个年龄段。据报道，18-21岁的人群比22-29岁的人群有更多的语言交流障碍，比40-49岁的人群有更多的限制和重复行为。根据受访者报告的当前症状，符合ASD诊断标准的男性百分比没有年龄组差异。破坏性行为有年龄相关差异的趋势。研究结果有助于理解成年期ASD症状的发展轨迹。
A cross-sectional analysis was used to examine age-related differences in ASD symptoms and corresponding differences in disruptive behavior and social skills in 281 adult men with Fragile X syndrome (FXS). Four age groups were created: 18–21 years, 22–29 years, 30–39 years, and 40–49 years. The 18–21 year-old group was reported to have more impairments in verbal communication than the 22–29 year-old group and more restricted and repetitive behaviors than the 40–49 year-old group. There was not an age-group difference in the percentage of men who met criteria for an ASD diagnosis based on respondent-reported, current symptoms. There was a trend for an age-related difference in disruptive behavior. Findings add to understanding of the developmental trajectory of ASD symptoms in adulthood.