Preparation of cyanoacrylate nanoparticles using monosaccharides or disaccharides
Preparation of cyanoacrylate nanoparticles using monosaccharides or disaccharides
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DOI：
10.1248/cpb.56.137
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发表时间：
2008-01-01
影响因子：
1.7
通讯作者：
Okuda, Kenji
中科院分区：
文献类型：
--
作者：
Shirotake, Shoichi;Tomita, Yu'usuke;Okuda, Kenji
以单糖和二糖生物材料为高分子稳定剂，分别制备了粒径约为200 nm或300 nm的氰基丙烯酸酯纳米粒子。新方法用于将氨苄西林 (ABPC) 和 pDNA 负载/封装到纳米颗粒中。与使用葡聚糖作为稳定剂的现有方法相比，ABPC 的装载效率有所提高。使用葡萄糖，pDNA 封装率为 68.7%。
By using biomaterials, including monosaccharides and disaccharides, as polymeric stabilizing agents, the cyanoacrylate nanoparticles was prepared respectively, with particles diameter of approximately 200 nm or 300 nm. The new method was applied to load/encapsulate ampicillin (ABPC) and pDNA into nanoparticles. Loading efficiency of ABPC was increased compared to the existing method in which dextran is used as a stabilizer. The pDNA encapusulation rate was 68.7%, by using glucose.