Bioactive Natural Products from Marine Sponges
Bioactive Natural Products from Marine Sponges
复制标题
DOI：
10.1142/9789812707444_0018
复制
发表时间：
2007-02
期刊：
影响因子：
--
通讯作者：
S. Bao;Biwen Wu;Hui-qin Huang
中科院分区：
文献类型：
--
作者：
S. Bao;Biwen Wu;Hui-qin Huang
海洋覆盖了地球的70.8%，拥有丰富的生物。这些海洋生物由于其多样的生存环境和漫长的进化历史，可能具有独特的代谢途径和遗传背景。因此，海洋生物提供新的生物活性产品的潜力巨大。这些活性产物主要在海藻、海星、海胆中检测到，尤其是在海绵中检测到。海绵是最原始的多细胞动物，已经存在了7 - 8亿年，大约有15，000种海绵物种。海绵通常与其他生物体共生，并且没有受到它们的攻击。20世纪50年代，Ara-U作为抗肿瘤先导化合物首次从海绵中分离出来，并导致抗肿瘤化合物Ara-C的合成。在过去的20年中，许多新的产品已被分离出的海绵和许多这些已显示出明显的生物活性。本文综述了海绵中具有抗肿瘤、抗病毒和抗菌活性的天然活性物质，以及海绵生物质的生产策略。
The ocean covers 70.8% of the earth and has abundant organisms. These marine organisms likely have unique metabolic pathway and genetic backpund because of their varied living envimnment and long evolutionary history. Thus the potential of marine organisms to provide new bioactive products is enormous. These active products have been detected mostly in marine algae, starfish, echinus and especially frequently in sponges. Sponges are the most primitive ofthe multi-celled animals that have existed for 700-800 million years and there are approximately 15,000 sponge species. Sponges often have associated symbiosis with other organisms and have not been attacked by them. In the 195O’s, Ara-U was fist isolated from marine sponge as a lead antitumor compound and has led to the synthesis of an antitumor compound, Ara-C. During the last 20 years, numerous novel products have been isolated from marine sponges and many of these have shown pronounced biological activity. This review summarizes the natural active products derived fiom marine sponges with antitumor, antiviral and antibacterial activities and also the strategies for producing sponge biomass.