BIOLOGIC VARIABLES IN THE HAIR UPTAKE OF METHYLMERCURY FROM BLOOD IN THE MACAQUE MONKEY
BIOLOGIC VARIABLES IN THE HAIR UPTAKE OF METHYLMERCURY FROM BLOOD IN THE MACAQUE MONKEY
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DOI：
10.1016/s0013-9351(87)80218-9
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发表时间：
1987-04-01
影响因子：
8.3
通讯作者：
BURBACHER, TM
中科院分区：
文献类型：
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作者：
MOTTET, NK;BODY, RL;BURBACHER, TM
45只年轻健康成年雌性褐尾猕猴每天口服苹果汁中的0、50、70或90 μ g MeHg/kg体重，其头发和血液中的总汞（Hg）显示血液汞和头发之间的比例接近且恒定。在给定的剂量水平下，头发中的汞含量不会随着时间的推移而增加（最长观察期为490天）。此外，背景剂量和亚毒性剂量水平之间的比值未发生变化。在给定剂量水平下，血液水平高于平均水平的个体的毛发水平按比例较高。猕猴的血液/毛发比率明显低于人类报告的比率。怀孕对头发汞含量没有明显影响。对人类和猕猴毛发生长和结构中的已知变量进行审查，未提供差异的解释。我们认为，一个尚未确定的生物学变量（S），可能是卵泡周围血流，可以解释这种差异。尽管存在这种比例差异，但对猕猴毛发的对照研究（如本研究）为终毛作为痕量金属暴露指示剂的有效性提供了支持。
The total mercury (Hg) in hair and blood of 45 young healthy adult female Macaque fuscicularis given 0, 50, 70, or 90 .mu.g MeHg/kg body wt orally in apple juice daily revealed a close and constant ratio between blood Hg and hair. The amount of hair Hg does not increase with time (maximum period of observation 490 days) at a given dose level. Also the ratio was unchanged between background and subtoxic dose levels. Individuals at a given dose level with a higher-than-average blood level had a proportionally higher hair level. The Macaque blood/hair ratio is markedly lower than that reported for humans. Pregnancy did not have an appreciable effect on the hair mercury level. Review of the known variables in human and Macaque hair growth and structure does not provide an explanation for the difference. We suggest that an as yet unidentified biological variable(s), possibly, circumfollicular blood flow, could account for the difference. This ratio difference notwithstanding, controlled studies on Macaque hair such as this add support for the validity of terminal hair as a trace metal exposure indicator.