How to Break a Ring: Exploring the Mechanisms of SAS-6 Oligomerisation
How to Break a Ring: Exploring the Mechanisms of SAS-6 Oligomerisation
复制标题
如何打破环：探索 SAS-6 寡聚化机制
DOI：
10.1016/j.bpj.2016.11.3047
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发表时间：
2017
影响因子：
3.4
通讯作者：
Busch J
中科院分区：
文献类型：
--
作者：
Busch J
中心粒是真核细胞中包含微管组织中心的圆柱形细胞器。因此，它们在不同的细胞功能中发挥重要作用，包括运动，信号传导和分裂。中心粒作为基体将鞭毛和纤毛锚在细胞膜上，而作为中心体，它们在染色体分离过程中参与纺锤体的协调。[Bornens 2012].Centriole数量受到严格控制，其复制是一个高度调节和保守的过程。[Azimzadeh和马歇尔2010]深入了解中心粒复制过程中起作用的分子机制将对我们理解基本细胞过程和许多疾病，包括癌症，小头畸形症甚至疟疾等原生动物感染产生影响。[Chavali et al 2014，Marques et al. 2015]。
Centrioles are cylindrical organelles that comprise the microtubule organising centres in eukaryotic cells. As such they play important roles for diverse cellular functions including locomotion, signalling and division. As basal bodies centrioles anchor flagella and cilia to the cell membrane, while as centrosomes they are involved in coordinating the spindle apparatus during chromosome segregation.[Bornens 2012].Centriole numbers are strictly controlled with their duplication being a highly regulated and conserved process.[Azimzadeh and Marshall 2010] Deeper insight into the molecular mechanisms at play in the centriole duplication process would have implications on our understanding of fundamental cell processes and a number of disease including cancer, microcephaly and even protozoan infections like malaria.[Chavali et al 2014, Marques et al. 2015].