Synthesis of quantum dot-tagged submicrometer polystyrene particles by miniemulsion polymerization
Synthesis of quantum dot-tagged submicrometer polystyrene particles by miniemulsion polymerization
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DOI：
10.1021/la052197k
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发表时间：
2006-02-14
期刊：
影响因子：
3.9
通讯作者：
Elaissari, A
中科院分区：
文献类型：
--
作者：
Joumaa, N;Lansalot, M;Elaissari, A
以CdSe/ZnS核-架量子点（QDs）为原料，通过细乳液聚合法合成了亚微米荧光聚苯乙烯（PS）粒子。分析了量子点浓度、量子点涂层（三辛基氧化膦（TOPO）涂层或乙烯基官能化）和表面活性剂浓度对所制备颗粒的聚合动力学和光致发光性能的影响。聚合动力学没有改变量子点的存在下，无论其表面涂层。乳胶表现出的粒径范围从100至350 nm，这取决于表面活性剂的浓度，并在所有情况下得到一个窄的粒径分布。颗粒的荧光信号随着掺入的TOPO涂覆的QD的数量而增加。发射最大值的轻微红移与PS和QD之间的相分离相关，所述相分离发生在聚合过程中，定位在颗粒/水界面附近的QD。与具有乙烯基部分的量子点相比，具有TOPO涂覆的量子点的量子点标记的颗粒显示出更高的荧光强度。所获得的荧光颗粒为生物技术中的各种应用开辟了新的机会。
Submicrometer fluorescent polystyrene (PS) particles have been synthesized via miniemulsion polymerization using CdSe/ZnS core-shelf quantum dots (QDs). The influence of QD concentration, QD coating (either trioctylphosphine oxide (TOPO)-coated or vinyl-functionalized), and surfactant concentration on the polymerization kinetics and the photoluminescence properties of the prepared particles has been analyzed. Polymerization kinetics were not altered by the presence of QDs, whatever their surface coating. Latexes exhibited particle sizes ranging from 100 to 350 nm, depending on surfactant concentration, and a narrow particle size distribution was obtained in all cases. The fluorescence signal of the particles increased with the number of incorporated TOPO-coated QDs. The slight red shift of the emission maximum was correlated with phase separation between PS and QDs, which occurred during the polymerization, locating the QDs in the vicinity of the particle/water interface. QD-tagged particles displayed higher fluorescence intensity with TOPO-coated QDs compared to those with the vinyl moiety. The obtained fluorescent particles open up new opportunities for a variety of applications in biotechnology.