Right hemisphere pitch-mismatch negativity reduction in patients with major depression: An MEG study.
Right hemisphere pitch-mismatch negativity reduction in patients with major depression: An MEG study.
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DOI：
10.1016/j.jad.2017.03.046
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发表时间：
2017-06
影响因子：
6.6
通讯作者：
Noriaki Hirakawa;Y. Hirano;I. Nakamura;S. Hirano;Jinya Sato;N. Oribe;T. Ueno;S. Kanba;T. Onitsuka
中科院分区：
文献类型：
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作者：
Noriaki Hirakawa;Y. Hirano;I. Nakamura;S. Hirano;Jinya Sato;N. Oribe;T. Ueno;S. Kanba;T. Onitsuka
背景事件相关电位（event-related potential，简称MMN）的负性失配（mismatch negativity，MMN）成分及其磁对应物MMNm是由异常刺激的物理特征与重复标准刺激产生的神经元感觉记忆轨迹之间的失配而产生的。在MMN/MMNm的缺陷已报告在重度抑郁症患者，但是，结果是不一致的。本研究采用全脑306通道脑磁图（MEG）对20例抑郁症患者和36例正常人进行了音高-MMMNm的研究。受试者提出了两个序列的听觉刺激。一个由1000 Hz标准信号（概率= 90%）和1200 Hz偏差信号（概率= 10%）组成，而另一个由1200 Hz标准信号（90%）和1000 Hz偏差信号（10%）组成。事件相关的大脑对标准音的反应被减去异常tones.ResultsMajor抑郁症患者的反应显示出显着降低磁全球场功率（GFP）的MMMm在右半球（p = 0.02），虽然没有显着的MMMm减少观察到在左半球（p = 0.81）。此外，抑郁症患者的双侧MMMNm峰值延迟时间显著提前（p = 0.004）。没有显着的协会之间观察到MMMm变量和人口统计学数据/临床变量patients.LimitationsWe不能排除抗抑郁药，情绪稳定剂，或抗精神病药物的影响，发现在重度抑郁症患者的MMMm异常。样本量也不足以允许亚组analysis.ConclusionsPatients与抑郁症表现出减少GFP的MMMn在右半球。本研究提示抑郁症患者可能存在右半球优势性前注意功能障碍。
BackgroundThe mismatch negativity (MMN) component of the event-related potential and its magnetic counterpart, the MMNm, are generated by a mismatch between the physical features of a deviant stimulus and a neuronal sensory-memory trace produced by repetitive standard stimuli. Deficits in the MMN/MMNm have been reported in patients with major depression; however, the results are inconsistent. The present study investigated the pitch-MMNm in patients with major depression using whole-head 306-channel magnetoencephalography (MEG).MethodsTwenty patients with major depression and 36 healthy subjects participated in this study. Subjects were presented with two sequences of auditory stimuli. One consisted of 1000 Hz standard signals (probability=90%) and 1200 Hz deviant signals (probability=10%), while the other consisted of 1200 Hz standard (90%) and 1000 Hz deviant signals (10%). Event-related brain responses to standard tones were subtracted from responses to deviant tones.ResultsMajor depressive patients showed significantly reduced magnetic global field power (GFP) of MMNm in the right hemisphere (p=0.02), although no significant MMNm reduction was observed in the left hemisphere (p=0.81). Additionally, patients with major depression showed significantly earlier bilateral MMNm peak latencies (p=0.004). No significant associations were observed between MMNm variables and demographic data/clinical variables within the patients.LimitationsWe could not exclude the effects of antidepressants, mood stabilizers, or neuroleptics on the MMNm abnormalities found in patients with major depression. Sample size was also insufficient to permit subgroup analyses.ConclusionsPatients with major depression exhibited reduced GFP of MMNm in the right hemisphere. The present study suggested that patients with major depression may have right hemispheric dominant preattentive dysfunction.