Acid-sensitive vagal sensory pathways and cough
Acid-sensitive vagal sensory pathways and cough
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DOI：
10.1016/j.pupt.2006.11.010
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Undem, Bradley J.
中科院分区：
文献类型：
--
作者：
Kollarik, Marian;Ru, Fei;Undem, Bradley J.
酸是咳嗽发病机制中的重要介质。吸入外源性酸引起咳嗽，内源性酸可能导致呼吸系统疾病的咳嗽。酸直接刺激调节咳嗽反射的迷走支气管感觉神经。与它们在防御吸入和吸入刺激物中的假定作用一致，大气道中的A5纤维伤害感受器通过快速酸化最有效地刺激。相比之下，C纤维伤害感受器的酸敏感特性允许连续监测pH，这在炎症中可能很重要。酸也是由胃食管反流（戈尔）引起的咳嗽的发病机制中最重要的介质。咳嗽通路可被来自食管的感觉输入敏化。这种致敏可能是由迷走食管感觉神经的一个子集介导的，其特征在于对伤害性刺激的辨别性反应（伤害感受器）。迷走感觉神经酸敏感性的受体尚未完全了解。TRPV1的作用已经确定，但酸敏感离子通道（ASIC）和其他受体的作用有待更明确的研究。在这里，我们提供了一个简短的概述咳嗽相关的酸敏感的感觉通路，并讨论酸敏感性的机制。(c)2007爱思唯尔有限公司保留所有权利。
Acid is an important mediator in the pathogenesis of cough. Inhalation of exogenous acid triggers cough and endogenous acid may contribute to cough in respiratory diseases. Acid directly stimulates vagal bronchopulmonary sensory nerves that regulate the cough reflex. Consistent with their putative role in defence against aspiration and inhaled irritants, A5-fibre nociceptors in the large airways are most efficiently stimulated by rapid acidification. In contrast, acid-sensitive properties of the C-fibre nociceptors allow for continuous monitoring of pH which is likely important in inflammation. Acid is also the single most important mediator in the pathogenesis of cough due to gastro-oesophageal reflux (GOR). The cough pathways can be sensitized by the sensory inputs from the oesophagus. This sensitization is likely mediated by a subset of the vagal oesophageal sensory nerves distinguished by discriminative responsiveness to noxious stimuli (nociceptors). The receptors underlying acid sensitivity of vagal sensory nerves are incompletely understood. The role of TRPV1, has been established but the roles of acid-sensing ion channels (ASIC) and other receptors await more definitive investigation. Here, we provide a brief overview of the cough-related acid-sensitive sensory pathways and discuss the mechanisms of acid sensitivity. (c) 2007 Elsevier Ltd. All rights reserved.