Evaluation and prediction of fluoroquinolone pharmacodynamics in bacterial keratitis.
Evaluation and prediction of fluoroquinolone pharmacodynamics in bacterial keratitis.
复制标题
细菌性角膜炎氟喹诺酮药效学的评价和预测。
DOI：
10.1089/108076803322473042
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Wilhelmus,KirkR
中科院分区：
文献类型：
--
作者：
Wilhelmus,KirkR
观察性研究表明，药效学指数有助于预测呼吸道和其他感染的治疗结果。本研究探讨了可达到的预后的重要性， 391例细菌性角膜炎患者角膜分离株的氟喹诺酮类药物的角膜水平与氟喹诺酮类药物的最小抑菌浓度（MIC）。峰浓度和峰下面积 角膜中的浓度曲线（AUC）由局部用环丙沙星获得的报道值估算。抑制商（IQ）计算为可达到的估计峰的比值 角膜环丙沙星浓度与角膜炎分离株的环丙沙星MIC的比值，抑制曲线下面积（AUIC）定义为预期的24小时AUC除以MIC。的概率 如果环丙沙星的IQ大于8或AUIC大于151，则环丙沙星治疗细菌性角膜炎的临床改善率为90%或更高。一种与角膜药代动力学相关的药效学指标 敏感性浓度可能与细菌性角膜炎对氟喹诺酮类药物治疗的临床反应有关。
Observational studies suggest that a pharmacodynamic index helps to predict the therapeutic outcome of respiratory and other infections. This study explored the prognostic importance of a ratio of the achievable corneal level for a fluoroquinolone to the fluoroquinolone's minimal inhibitory concentration (MIC) for corneal isolates of 391 patients with bacterial keratitis. The peak concentration and the area under the concentration curve (AUC) in the cornea were estimated from reported values achieved with topical ciprofloxacin. The inhibitory quotient (IQ) was calculated as the ratio of the estimated peak achievable corneal ciprofloxacin concentration to the ciprofloxacin MIC of keratitis isolates, and the area under the inhibitory curve (AUIC) was defined as the expected 24-hour AUC divided by the MIC. The probability of clinical improvement of ciprofloxacintreated bacterial keratitis was 90% or more if ciprofloxacin's IQ was above 8 or the AUIC was greater than 151. A pharmacodynamic index relating corneal pharmacokinetic and susceptibility concentrations may correlate with the clinical response of bacterial keratitis to fluoroquinolone therapy.