Correlates of residual fatigue in patients with major depressive disorder: The role of psychotropic medication
Correlates of residual fatigue in patients with major depressive disorder: The role of psychotropic medication
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DOI：
10.1016/j.jad.2015.07.026
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发表时间：
2015-11-01
影响因子：
6.6
通讯作者：
Yeung, Wing-Fai
中科院分区：
文献类型：
--
作者：
Chung, Ka-Fai;Yu, Yee-Man;Yeung, Wing-Fai
目的：疲劳既是重性抑郁障碍（MDD）的核心症状，也是常见的残留症状。我们确定的社会人口，临床和药理学因素，与疲劳的缓解或部分缓解的MDD。方法：数据来自一项随机对照试验，针刺在137例MDD患者的残留症状。采用多维疲劳量表（MFI-20）测量疲劳。自我报告和临床医生评定量表被用来评估精神病理学。17-结果：本组患者平均HDRS 17评分为10.5分，缓解率为29.2%。平均MFI-20评分为71.8分; 83.2%的患者有严重疲劳，定义为MFI-20评分≥ 60分。137名参与者中有52名（38%）使用镇静精神药物。抗抑郁药剂量范围为1-90 mg氟西汀当量，镇静剂/催眠药范围为1-60 mg地西泮当量。MFI-20评分与HDRS 17抑郁和焦虑分项评分、医院焦虑和抑郁量表（HADS）抑郁和焦虑分项评分以及疼痛灾难化量表评分之间存在显著相关性，但失眠和日间嗜睡、社会人口统计学、当前医疗状况和精神药物使用之间无显著相关性。多重回归分析。RADS和HDRS 17抑郁评分独立预测MFI-20评分。在缓解和部分缓解亚组，RADS抑郁评分是一个独立的predictor.Limitation：参与者招募专业精神科单位，因此，调查结果可能不适用于非专业setting.Conclusion：疲劳预测抑郁症的严重程度在缓解或部分缓解的MDD。精神药物和更高剂量与更大的疲劳无关。(C)2015爱思唯尔B. V.保留所有权利。
Objective: Fatigue is nor only a core symptom of major depressive disorder (MDD), but also a common residual symptom. We determined the sociodemographic, clinical, and pharmacologic factors that were associated with Fatigue in patients with remission or partial remission of MDD.Methods: Data was derived from a randomized controlled trial of acupuncture in 137 MDD patients with residual symptoms. Fatigue was measured by Multidimensional Fatigue Inventory (MFI-20). Self-report and clinician-rated scales were used to assess psychopathology. 17-item Hamilton Depression Rating Scale (HDRS17) score < 7 denoted MDD remission.Results: Participants' average HDRS17 score was 10.5, 29.2% were in remission. The average MFI-20 score was 71.8; 83.2% had severe fatigue, defined as MFI-20 score >= 60. Fifty-two of 137 participants (38%) were using sedating psychotropic medications. Antidepressant dosage ranged from 1-90 mg fluoxetine equivalent and sedatives/hypnotics from 1-60 mg diazepam equivalent. There were significant correlations between MFI-20 score and HDRS17 depression and anxiety subscores, Hospital Anxiety and Depression Scale (HADS) depression and anxiety subscores, and Pain Catastrophizing Scale score, but insomnia and daytime sleepiness, sociodemographics, current medical conditions, and psychotropic medication use were not significant correlates. Upon multiple regression. RADS and HDRS17 depression scores independently predicted MFI-20 score. In remission and partial remission subgroups, RADS depression score was an independent predictor.Limitation: Participants were recruited from specialty psychiatric units; hence the findings may not be applicable in non-specialized settings.Conclusion: Fatigue was predicted by depression severity in remitted or partially remitted MDD. Psychotropic medication and higher dosage were not associated with greater fatigue. (C) 2015 Elsevier B.V. All rights reserved.