A Magnetic Resonance Spectroscopy Study of Brain Glutamate in a Model of Plasticity in Human Pharyngeal Motor Cortex
A Magnetic Resonance Spectroscopy Study of Brain Glutamate in a Model of Plasticity in Human Pharyngeal Motor Cortex
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DOI：
10.1053/j.gastro.2008.10.087
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发表时间：
2009-02-01
期刊：
影响因子：
29.4
通讯作者：
Hamdy, Shaheen
中科院分区：
文献类型：
--
作者：
Singh, Saul;Mistry, Satish;Hamdy, Shaheen
背景与目的：外周刺激和皮层刺激（配对联想刺激[PAS]）的协同传递已被证明可诱导肢体运动皮层的可塑性，然而，其在咽运动皮层中的应用以及参与人类神经可塑性的分子机制仍不确定。由于神经可塑性似乎是脑损伤后消化功能如吞咽功能恢复的基础，本研究的目的是通过将PAS应用于咽肌肉组织来表征人咽运动皮层皮层可塑性的诱导，并探讨谷氨酸在这一过程中的潜在作用。方法：15名健康志愿者完成一系列实验，通过经颅磁刺激反应的咽运动诱发电位振幅来评估皮层兴奋性。初步研究了双侧咽部系统中PAS的最佳参数和半球间相互作用。然后用磁共振波谱法评估PAS后的皮质谷氨酸。结果：配对刺激间隔100 ms时，咽皮层兴奋性增加最大(F[15,210] = 2.28
Background & Aims: Coordinated delivery of peripheral and cortical stimuli (paired associative stimulation [PAS]) has been shown to induce plasticity in limb motor cortex, however, its application in pharyngeal motor cortex and the molecular mechanisms involved in human neuroplasticity remain uncertain. Because neuroplasticity appears to form the basis for functional recovery of digestive functions such as swallowing after brain injury, the aim of this study was to characterize the induction of cortical plasticity in human pharyngeal motor cortex through PAS applied to pharyngeal musculature and investigate the potential role of glutamate in this process. Methods: Fifteen healthy volunteers completed a series of experiments in which cortical excitability was assessed through pharyngeal motor evoked potential amplitudes in response to transcranial magnetic stimulation. The optimal parameters and interhemispheric interactions of PAS in the bilaterally represented pharyngeal system initially were investigated. Cortical glutamate after PAS then was assessed with magnetic resonance spectroscopy. Results: The greatest increase in cortical pharyngeal excitability was seen if paired stimuli were separated by 100 ms (F[15,210] = 2.28; P