Streptocidins A∼D, novel cyclic decapeptide antibiotics produced by Streptomyces sp Tu 6071 I.: Taxonomy, fermentation, isoltation anal biological activities
Streptocidins A∼D, novel cyclic decapeptide antibiotics produced by Streptomyces sp Tu 6071 I.: Taxonomy, fermentation, isoltation anal biological activities
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DOI：
10.7164/antibiotics.54.428
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发表时间：
2001-05-01
影响因子：
3.3
通讯作者：
Fiedler, HP
中科院分区：
文献类型：
--
作者：
Gebhardt, K;Pukall, R;Fiedler, HP
采用高效液相色谱-二极管阵列和高效液相色谱-电喷雾质谱联用技术，从链霉菌Tu 6071菌丝体提取物中检测到4种非环状高十肽类抗生素，即链菌素A和D。短芽孢杆菌的短杆菌肽与短杆菌肽在结构上密切相关，对革兰氏阳性菌具有抗菌活性。
Four never cyclic homodecapetide antibiotics, streptocidins A similar toD were detected in the mycelium extract of Streptomyces sp. Tu 6071 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The peptides which were closely related in structure to the tyrocidines and gramicidins of Bacillus brevis show antibiotic activities against Gram-positive bacteria.