Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective.
Follicular CD4 T Helper Cells As a Major HIV Reservoir Compartment: A Molecular Perspective.
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DOI：
10.3389/fimmu.2018.00895
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发表时间：
2018
影响因子：
7.3
通讯作者：
Ribeiro SP
中科院分区：
文献类型：
--
作者：
Aid M;Dupuy FP;Moysi E;Moir S;Haddad EK;Estes JD;Sekaly RP;Petrovas C;Ribeiro SP
有效的抗逆转录病毒治疗（ART）可以防止大多数感染者发展为艾滋病，并降低与艾滋病毒相关的发病率和死亡率。然而，终身接受抗逆转录病毒疗法是必要的，这给个人和公共卫生系统带来了过重的负担。因此，发现能够根除或功能性治愈HIV感染的治疗方案非常重要。 ART 中断会导致病毒反弹，突出显示即使在长期治疗下，潜伏病毒储存室的建立和维持也是如此。据报道，滤泡辅助 CD4 T 细胞 (TFH) 是导致病毒持久性的主要细胞区室，因为它们对感染敏感且能够释放具有复制能力的新病毒颗粒。在这里，我们讨论了支持 TFH 细胞作为主要 HIV 储存库之一的分子特征和潜在机制。
Effective antiretroviral therapy (ART) has prevented the progression to AIDS and reduced HIV-related morbidities and mortality for the majority of infected individuals. However, a lifelong administration of ART is necessary, placing an inordinate burden on individuals and public health systems. Therefore, discovering therapeutic regimens able to eradicate or functionally cure HIV infection is of great importance. ART interruption leads to viral rebound highlighting the establishment and maintenance of a latent viral reservoir compartment even under long-term treatment. Follicular helper CD4 T cells (TFH) have been reported as a major cell compartment contributing to viral persistence, consequent to their susceptibility to infection and ability to release replication-competent new virions. Here, we discuss the molecular profiles and potential mechanisms that support the role of TFH cells as one of the major HIV reservoirs.