Deregulated NF-kappaB activity in haematological malignancies.
Deregulated NF-kappaB activity in haematological malignancies.
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DOI：
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发表时间：
2006
影响因子：
5.8
通讯作者：
A. Keutgens;I. Robert;P. Viatour;A. Chariot
中科院分区：
文献类型：
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作者：
A. Keutgens;I. Robert;P. Viatour;A. Chariot
NF-κ B家族转录因子在细胞增殖和凋亡的调控中起着关键作用。组成性NF-κ B活化是大多数血液恶性肿瘤的共同特征，因此被认为是这些恶性细胞增殖和存活增强的关键事件。在这篇综述中，我们将描述血液恶性肿瘤中NF-κ B失调的分子机制，并将强调在发现这种转录因子20年后，在这一领域仍不清楚的内容。
The NF-kappaB family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappaB activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappaB deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor.