IMMUNE FUNCTION IN GROWTH HORMONE-DEFICIENT CHILDREN TREATED WITH BIOSYNTHETIC GROWTH-HORMONE
IMMUNE FUNCTION IN GROWTH HORMONE-DEFICIENT CHILDREN TREATED WITH BIOSYNTHETIC GROWTH-HORMONE
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DOI：
10.1111/j.1651-2227.1991.tb11733.x
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发表时间：
1991-01-01
期刊：
影响因子：
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通讯作者：
BOSCHERINI, B
中科院分区：
文献类型：
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作者：
SPADONI, GL;ROSSI, P;BOSCHERINI, B
据报道，有关生长激素 (GH) 缺乏儿童的免疫功能或 GH 替代治疗期间免疫参数变化的数据存在矛盾。 我们研究了 13 名 GH 缺乏症患者在生物合成 GH（12 IU/m2 体表面积/周）治疗前和治疗期间、治疗 6 个月和 12 个月后的免疫功能。 我们发现总 T 淋巴细胞和 T 细胞亚群的绝对数量（使用单克隆抗体作为标记）、自然杀伤细胞活性（靶标 K562）以及淋巴细胞对多克隆有丝分裂原（PHA、ConA、PWM）的反应均在正常范围内，并且在治疗 6 个月和 12 个月后仍保持在正常范围内。 B淋巴细胞绝对数在治疗前和治疗6个月后处于正常范围，但在治疗12个月后显着下降。 血清免疫球蛋白（IgG、IgA、IgM）没有出现平行下降，在整个研究过程中保持正常。 我们的 GH 缺乏患者没有表现出任何对感染的过度易感性，因此我们的数据似乎证实了这些儿童的免疫功能基本完好，并且 GH 治疗不会抑制免疫功能。 尽管观察到 B 淋巴细胞下降，但免疫球蛋白的正常水平和对 PWM 的正常功能反应似乎证明了正常体液免疫反应的维持。
Conflicting data regarding the immune function in growth hormone (GH) -deficient children or changes in immune parameters during substitutive GH therapy have been reported. We have studied the immune function in 13 patients with GH deficiency before and during treatment with biosynthetic GH (12 IU/m2 body surface/week) after 6 and 12 months of therapy. We found that the absolute number of total T lymphocytes and T-cell subsets (using monoclonal Ab as markers), Natural Killer cell activity (target K562) and response of lymphocytes to polyclonal mitogens (PHA, ConA, PWM) were all in the normal range and remained so after 6 and 12 months of therapy. The absolute number of B lymphocytes was in the normal range before treatment and after 6 months of therapy but dropped significantly after 12 months of treatment. Serum immunoglobulins (IgG, IgA, IgM) did not show a parallel drop and remained normal throughout the whole study. Our GH-deficient patients did not show any undue susceptibility to infections and our data thus seem to confirm that the immune function is basically intact in these children and that it is not suppressed by GH treatment. Although a drop in B lymphocytes was observed, the normal level of immunoglobulins and the normal functional response to PWM seem to demonstrate the maintenance of a normal humoral immune response.