Beyond adrenal and ovarian androgen generation:: Increased peripheral 5α-reductase activity in women with polycystic ovary syndrome
Beyond adrenal and ovarian androgen generation:: Increased peripheral 5α-reductase activity in women with polycystic ovary syndrome
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DOI：
10.1210/jc.2002-021875
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发表时间：
2003-06-01
影响因子：
5.8
通讯作者：
Arlt, W
中科院分区：
文献类型：
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作者：
Fassnacht, M;Schlenz, N;Arlt, W
高雄激素血症是多囊卵巢综合征（PCOS）的一个主要临床特征，被认为是由于卵巢和肾上腺雄激素生成增强所致。为了研究外周类固醇生成的贡献，我们使用脱氢表雄酮 (DHEA) 进行口服激发，并分析了 8 名 PCOS 女性（年龄 20-32 岁；体重指数 20-41 kg/m(2)）和 8 名年龄和体重指数匹配的健康女性的雄激素下游转化情况。他们在 3 个场合进行了 8 小时的频繁血清采样和尿液收集：基线时和地塞米松（Dex；4x0.5 mg/d）4 天后，随后摄入 100 mg DHEA 或安慰剂。地塞米松对两组中循环类固醇的抑制作用相似。口服 DHEA 挑战导致血清 DHEA、硫酸 DHEA、雄烯二酮和睾酮的浓度-时间曲线下面积（Dex 后 0-8 小时）出现类似的显着增加。然而，口服 DHEA 后，PCOS 女性的血清 5α-二氢睾酮水平显着升高（P
Hyperandrogenism, a main clinical feature of polycystic ovary syndrome (PCOS), is thought to result from enhanced ovarian and adrenal androgen generation. To investigate the contribution of peripheral steroidogenesis, we used an oral challenge with dehydroepiandrosterone (DHEA) and analyzed its downstream conversion toward androgens in eight women with PCOS (age, 20-32 yr; body mass index, 20-41 kg/m(2)) and eight healthy women matched for age and body mass index. They underwent frequent serum sampling and urine collection for 8 h on three occasions: at baseline, and after 4 d of dexamethasone (Dex; 4x0.5 mg/d), followed by ingestion of 100 mg DHEA or placebo. Dex induced similar significant suppression of circulating steroids in both groups. The oral DHEA challenge led to similar significant increases in the area under the concentration-time curve (0-8 h after Dex) of serum DHEA, DHEA sulfate, androstenedione, and testosterone. However, after oral DHEA, PCOS women had significantly higher increases in serum 5alpha-dihydrotestosterone (P