Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals
Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals
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DOI：
10.1016/s0092-8674(00)80301-3
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发表时间：
1997-06-27
期刊：
影响因子：
64.5
通讯作者：
Mazat, JP
中科院分区：
文献类型：
--
作者：
Ichas, F;Jouaville, LS;Mazat, JP
我们报道了依赖于通透性转换孔（PTP）在低电导模式下短暂开放的线粒体钙离子诱导的钙离子释放（mCICR）。mCICR过程中发生的钙离子通量是PTP开放导致的线粒体去极化峰值（mDPS）的直接结果。在体外，mDPS和mCICR都能从一个线粒体传播到另一个线粒体，产生传播性的去极化和钙离子波。因此，线粒体似乎是能够产生和传递电信号及钙离子信号的可兴奋细胞器。在活细胞中，mDPS/mCICR在三磷酸肌醇（IP3）诱导的钙离子动员过程中被触发，并导致主要由内质网发出的钙离子信号放大。
We report Ca2+-induced release of Ca2+ from mitochondria (mCICR) dependent on transitory opening of the permeability transition pore (PTP) operating in a low conductance mode. The Ca2+ fluxes taking place during mCICR are a direct consequence of the mitochondrial depolarization spike (mDPS) caused by PTP opening. Both mDPS and mCICR can propagate from one mitochondrion to another in vitro, generating traveling depolarization and Ca2+ waves. Mitochondria thus appear to be excitable organelles capable of generating and conveying electrical and Ca2+ signals. In living cells, mDPS/mCICR is triggered during IP3-induced Ca2+ mobilization and results in the amplification of the Ca2+ signals primarily emitted from the endoplasmic reticulum.