Ventral cochlear nucleus neural discharge characteristics in the absence of outer hair cells.
Ventral cochlear nucleus neural discharge characteristics in the absence of outer hair cells.
复制标题
在没有外毛细胞的情况下，腹侧耳蜗核神经放电特征。
DOI：
10.1016/0006-8993(85)91119-9
复制
发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
Ryan,AF
中科院分区：
文献类型：
--
作者：
Woolf,NK;Ryan,AF
耳蜗外毛细胞（OHC）在听觉加工中的作用仍然知之甚少。OHCs具有独立的传入神经支配，占耳蜗传入神经元的5-10%，并似乎投射到耳蜗核（CN）。OHCs是否对CN中听觉信号的处理有贡献尚未确定。为了解决这个问题，研究人员利用卡那霉素耳毒性在龙猫耳蜗基底部分产生选择性OHC损失的同时，使内毛细胞（IHC）群体基本保持完整。然后在腹侧耳蜗核（VCN）中记录单单位反应，并与未治疗受试者的反应进行比较。在VCN神经反应中观察到的许多变化反映了先前在viii神经中报道的变化。然而，频率调谐曲线尖端段在带宽和长度上都是正常的，大约22%的单位与完全热含量损失和ihc保存的区域相关。这在以往的OHC病变研究中未见报道。此外，发现与OHC无区相关的单元的第一峰潜伏期显着延长。VCN神经反应的特征首先出现在CN内，如非原发的刺激后直方图反应模式，不受OHC损失的影响。这些结果表明，与OHCs相关的传入纤维在VCN的信号处理中并不起主要作用。
The role of the cochlear outer hair cell (OHC) in auditory processing remains poorly understood. The OHCs possess an independent afferent innervation which constitutes 5–10% of cochlear afferent neurons and which appears to project to the cochlear nucleus (CN). Whether the OHCs contribute to the processing of auditory signals in the CN has not been determined. To address this question, kanamycin ototoxicity was used to produce selective OHC loss while leaving the inner hair cell (IHC) population largely intact, in the basal portion of the cochlea of chinchillas. Single unit responses were then recorded in the ventral cochlear nucleus (VCN), and compared to responses in untreated subjects. Many of the changes observed in VCN neural responses reflected changes which have previously been reported in the VIIIth nerve. However, frequency tuning curve tip segments which were normal in both bandwidth and length were observed in approximately 22% of the units associated with regions of complete OHC loss and preservation of IHCs. This has not been reported in previous OHC lesion studies. Also, first spike latency was found to be significantly lengthened for units associated with the OHC free regions. Those features of VCN neural responses which first arise within the CN, such as non-primary-like post-stimulus-time histogram response patterns, were unaffected by OHC loss. These results suggest that afferent fibers associated with OHCs do not play a major role in signal processing in the VCN.