The cerebral cortex in cerebral amyloid angiopathy.
The cerebral cortex in cerebral amyloid angiopathy.
复制标题
脑淀粉样血管病中的大脑皮层。
DOI：
10.1016/s1474-4422(16)30100-4
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Schneider,JulieA
中科院分区：
文献类型：
--
作者：
Schneider,JulieA
It is well recognised that the cerebral cortex atrophies with age, particularly in people with cognitive decline or dementia. This phenomenon has been most commonly linked with Alzheimer’s disease. 1 There are few data about the role of other age-related pathologies, including small vessel disease, which often coexists with Alzheimer’s disease pathology in the aging brain. Cerebral amyloid angiopathy (CAA) is a small vessel disease that is common in old age, in patients with Alzheimer’s disease, and also occurs in rare heritable forms. CAA is defined by the deposition of amyloid in the leptomeningeal and cortical vessels, and can result in intracerebral haemorrhages, white matter hyperintensities, microinfarcts, microbleeds, and superficial siderosis. CAA is related to cognitive impairment and dementia in aging, but has been suggested to be independent of Alzheimer’s disease pathology and infarcts. 2 There are few data about the association between CAA and cortical atrophy, mostly because studies are confounded by coexisting Alzheimer’s disease pathology. Determining whether CAA and other small vessel disease pathologies are independently related to cortical atrophy could inform clinical differential diagnosis, vascular mechanisms in cognitive impairment, and biomarker development.
