EFFECTS OF PROSTAGLANDINS ON INTRAOCULAR PRESSURE OF RABBIT
EFFECTS OF PROSTAGLANDINS ON INTRAOCULAR PRESSURE OF RABBIT
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DOI：
10.1111/j.1476-5381.1969.tb09533.x
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发表时间：
1969-01-01
影响因子：
7.3
通讯作者：
EAKINS, KE
中科院分区：
文献类型：
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作者：
BEITCH, BR;EAKINS, KE
1. 研究了眼内注射前列腺素E1、E2、F1a、F2a和A1对聚氨酯麻醉家兔眼压的影响。2. 除前列腺素F1a外，研究发现所有前列腺素都能导致IOP持续大幅升高，并在许多病例中伴有瞳孔缩小。3. 所有研究的前列腺素对重复注射的反应都明显下降；这种效果在对前列腺素有较大的初始反应后更为明显。4. 前列腺素E1≈E2>F2a>A1>F1a提高IOP能力的效价递减顺序为：前列腺素E1≈E2>F2a>A1>F1a。5. 肠腔内注射前列腺素E1和E2导致房水蛋白含量增加，这与IOP持续增加的幅度有关。6. 用磷酸多酚黄素稳定血水屏障可显著降低IOP反应和前列腺素E2对房水蛋白含量的影响。7. 由此可见，前列腺素对IOP的影响与局部血管扩张和血水屏障通透性的增加有关。本文讨论了前列腺素在兔眼刺激反应中的作用。
1. The effects of intracameral injections of prostaglandins E1, E2, F1a, F2a, and A1 were studied on the intraocular pressure (IOP) of rabbits anaesthetized with urethane. 2. With the exception of prostaglandin F1a, all the prostaglandins studied were found to be capable of producing a large, sustained rise in IOP, accompanied in many cases by miosis. 3. A marked decrease in response to repeated injections was found with all the prostaglandins studied; this effect was more pronounced following a large initial response to the prostaglandin. 4. The descending order of potency in their ability to raise IOP was as follows: prostaglandin E1≈E2>F2a>A1>F1a. 5. Intracameral injections of prostaglandins E1 and E2 resulted in an increase in the protein content of the aqueous humour, which was related to the magnitude of the sustained increase in IOP. 6. Stabilization of the blood-aqueous barrier with polyphloretin phosphate markedly reduced both the IOP response and the effect of prostaglandin E2 on the protein content of the aqueous humour. 7. It is concluded that the production of local vasodilatation and increased permeability of the blood-aqueous barrier play an important part in the effect of prostaglandins on the IOP. The involvement of prostaglandins in the response of the rabbit eye to irritation is discussed.