Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring.
Maternal Factors that Induce Epigenetic Changes Contribute to Neurological Disorders in Offspring.
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DOI：
10.3390/genes8060150
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发表时间：
2017-05-24
期刊：
影响因子：
3.5
通讯作者：
Dheen ST
中科院分区：
文献类型：
--
作者：
Banik A;Kandilya D;Ramya S;Stünkel W;Chong YS;Dheen ST
众所周知，表观遗传因素的调控，包括染色质重组、组蛋白修饰、DNA甲基化和miRNA调控，对人类大脑的正常发育和功能至关重要。有许多母体因素影响表观遗传途径，如生活方式，包括饮食、饮酒和吸烟，以及年龄和感染（病毒或细菌）。遗传和代谢改变，如肥胖、妊娠糖尿病（GDM）和甲状腺功能障碍，改变了表观遗传机制，从而导致神经发育障碍（NDs），如胚胎神经管缺陷（NTDs）、自闭症、唐氏综合征、Rett综合征和晚发性神经心理缺陷。这篇综述全面描述了最近的发现，在表观遗传学景观有助于改变分子谱导致NDs。此外，我们将讨论未来研究的潜在途径，以确定诊断标记和治疗性表观遗传药物，以逆转大脑中的这些异常，因为表观遗传标记具有可塑性和可逆性。
It is well established that the regulation of epigenetic factors, including chromatic reorganization, histone modifications, DNA methylation, and miRNA regulation, is critical for the normal development and functioning of the human brain. There are a number of maternal factors influencing epigenetic pathways such as lifestyle, including diet, alcohol consumption, and smoking, as well as age and infections (viral or bacterial). Genetic and metabolic alterations such as obesity, gestational diabetes mellitus (GDM), and thyroidism alter epigenetic mechanisms, thereby contributing to neurodevelopmental disorders (NDs) such as embryonic neural tube defects (NTDs), autism, Down’s syndrome, Rett syndrome, and later onset of neuropsychological deficits. This review comprehensively describes the recent findings in the epigenetic landscape contributing to altered molecular profiles resulting in NDs. Furthermore, we will discuss potential avenues for future research to identify diagnostic markers and therapeutic epi-drugs to reverse these abnormalities in the brain as epigenetic marks are plastic and reversible in nature.