Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes
Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes
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DOI：
10.1007/s00125-018-4708-x
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发表时间：
2018-11-01
期刊：
影响因子：
8.2
通讯作者：
Hessner, Martin J.
中科院分区：
文献类型：
--
作者：
Cabrera, Susanne M.;Engle, Samuel;Hessner, Martin J.
该研究旨在根据临床发病时的免疫调节特征来确定是否存在 1 型糖尿病的离散亚型，因为这对疾病的治疗和预防以及临床试验的设计和分析具有重要意义。我们使用基于血浆的转录生物测定和基于基因本体的评分算法，检查了威斯康星州儿童医院的当地参与者，并对 TrialNet CTLA4-Ig 试验 (TN-09) 参与者进行了辅助分析。发病后期间测量的炎症/调节平衡变化很大。值得注意的是，在安慰剂治疗的个体中，基线先天炎症活动与发病后 3、6、12、18 和 24 个月测量的刺激 C 肽 AUC 之间存在显着的负相关关系 (p
The study aimed to determine whether discrete subtypes of type 1 diabetes exist, based on immunoregulatory profiles at clinical onset, as this has significant implications for disease treatment and prevention as well as the design and analysis of clinical trials.Using a plasma-based transcriptional bioassay and a gene-ontology-based scoring algorithm, we examined local participants from the Children's Hospital of Wisconsin and conducted an ancillary analysis of TrialNet CTLA4-Ig trial (TN-09) participants.The inflammatory/regulatory balance measured during the post-onset period was highly variable. Notably, a significant inverse relationship was identified between baseline innate inflammatory activity and stimulated C-peptide AUC measured at 3, 6, 12, 18 and 24 months post onset among placebo-treated individuals (p