Mx proteins: mediators of innate resistance to RNA viruses
Mx proteins: mediators of innate resistance to RNA viruses
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DOI：
10.20506/rst.17.1.1084
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发表时间：
1998-04-01
期刊：
影响因子：
--
通讯作者：
Kochs, G
中科院分区：
文献类型：
--
作者：
Haller, O;Frese, M;Kochs, G
Mx蛋白是由干扰素诱导的大型鸟苷三磷酸酶发动蛋白超家族的成员。这些蛋白引起了人们的注意，因为一些蛋白显示出抗病原性RNA病毒的抗病毒活性，例如抗正粘病毒（流感病毒）家族或布尼亚病毒家族的成员。表达Mr蛋白的转染细胞和转基因小鼠对Mx敏感病毒具有高度抗性，表明Mr蛋白是强大的抗病毒剂。在人类中，在自限性病毒感染期间观察到MxA的合成，因此可能促进疾病的恢复。
Mx proteins are interferon-induced members of the dynamin superfamily of large guanosine triphosphatases. These proteins have attracted attention because some display antiviral activity against pathogenic RNA viruses, for example against members of the orthomyxovirus (influenzavirus) family or the bunyavirus family. Transfected cells and transgenic mice expressing Mr proteins are highly resistant to Mx-sensitive viruses, demonstrating that Mr proteins are powerful antiviral agents. In humans, synthesis of MxA is observed during self-limiting viral infections and may thus promote recovery from disease.