Anterior Cingulate Cortex and Symptom Severity in Attention-Deficit/Hyperactivity Disorder
Anterior Cingulate Cortex and Symptom Severity in Attention-Deficit/Hyperactivity Disorder
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DOI：
10.1037/a0032390
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发表时间：
2013-05-01
影响因子：
4.6
通讯作者：
Pliszka, Steven R.
中科院分区：
文献类型：
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作者：
Bledsoe, Jesse C.;Semrud-Clikeman, Margaret;Pliszka, Steven R.
注意力缺陷/多动障碍（ADHD）的病因与前额叶-纹状体-小脑网络的异常有关，但大脑-行为之间的相关性相对模糊。患有多动症的儿童和健康对照组接受了核磁共振成像和神经心理学测试。对双侧吻侧和尾侧前扣带皮层（ACC）进行脑皮质厚度分析。采用Stroop抑制测试评估抑制控制，采用家长和教师行为问卷评估ADHD症状严重程度。用回归模型计算皮质厚度与行为测量之间的脑行为关系。经多重比较统计校正后，ADHD儿童的右吻侧前扣带皮层明显变薄，但与健康对照儿童相比，右尾侧、左尾侧或左吻侧前扣带皮层无显著变薄。此外，右吻侧ACC厚度预测了父母和老师报告的ADHD症状的显著差异。探索性分析显示，皮质厚度与精神兴奋剂用药史无关。多动症的症状可能与右前注意网络皮层厚度的减少有关，右前注意网络是一个涉及行为错误检测、冲动和抑制控制的区域。
The cause of attention-deficit/hyperactivity disorder (ADHD) has been linked to abnormalities in prefrontal-striatal-cerebellar networks, but the brain-behavioral correlates are relatively equivocal. Children with ADHD and healthy controls underwent MRI and neuropsychological testing. Brain cortical thickness was analyzed for the bilateral rostral and caudal anterior cingulate cortex (ACC). Inhibitory control was assessed with the Stroop Inhibition test, and ADHD symptom severity was assessed with parent and teacher behavioral questionnaires. Brain-behavior relationships were calculated between cortical thickness and behavioral measures with regression models. Children with ADHD had significant cortical thinning in the right rostral ACC but nonsignificant thinning in right caudal, left caudal, or left rostral ACC compared with healthy control children after statistical correction for multiple comparisons. Further, right rostral ACC thickness predicted a significant amount of the variance in parent- and teacher-reported symptoms of ADHD. Exploratory analysis showed that cortical thickness was not related to psychostimulant medication history. Symptoms of ADHD may be related to reductions in cortical thickness in the right anterior attention network, a region implicated in behavioral error detection, impulsivity, and inhibitory control.