Paternal age and risk of schizophrenia in adult offspring.
Paternal age and risk of schizophrenia in adult offspring.
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DOI：
10.1097/00006254-200302000-00005
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发表时间：
2002-09
期刊：
影响因子：
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通讯作者：
Alan S. Brown;C. Schaefer;R. Wyatt;M. Begg;R. Goetz;M. Bresnahan;J. Harkavy-Friedman;J. Gorman;D. Malaspina;E. Susser
中科院分区：
文献类型：
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作者：
Alan S. Brown;C. Schaefer;R. Wyatt;M. Begg;R. Goetz;M. Bresnahan;J. Harkavy-Friedman;J. Gorman;D. Malaspina;E. Susser
目的 该研究探讨了父亲出生时的年龄与成年后代患精神分裂症的风险之间的关系。方法 本研究使用了精神分裂症产前决定因素研究出生队列的数据。事实上，该出生队列的所有成员都拥有有关后代出生时父亲年龄的前瞻性信息。该出生队列成员中患有精神分裂症和其他精神分裂症谱系障碍的受试者（N = 71）之前已被确定。在单独的分析中，将父亲年龄建模为连续变量和钙类别变量，并分别检查其与成人精神分裂症和其他精神分裂症谱系障碍的风险以及与精神分裂症风险的关系。结果 父亲年龄的增长与成人精神分裂症和精神分裂症谱系障碍的风险之间存在轻微显着的单调关联。在分析控制了母亲年龄和其他潜在混杂因素的影响后，该关联成立。当分析中仅包括精神分裂症受试者时，观察到类似的结果。结论 后代出生时父亲年龄较高可能是成年精神分裂症的危险因素。
OBJECTIVE The study examined the relation between paternal age at the time of birth and risk of schizophrenia in the adult offspring. METHOD Data from the birth cohort of the Prenatal Determinants of Schizophrenia study were used in this study. Virtually all members of this birth cohort had prospective information about paternal age at the time of the offspring's birth. Subjects with schizophrenia and other schizophrenia spectrum disorders (N=71) among members of this birth cohort were previously ascertained. In separate analyses, paternal age was modeled as a continuous variable and as a categorical variable, and its relation with the risk of adult schizophrenia and other schizophrenia spectrum disorders and with the risk of schizophrenia separately were examined. RESULTS There was a marginally significant, monotonic association between advancing paternal age and risk of adult schizophrenia and schizophrenia spectrum disorders. The association held after the analysis controlled for the effects of maternal age and other potential confounders. Similar results were observed when only subjects with schizophrenia were included in the analysis. CONCLUSIONS Advanced paternal age at the time of birth of the offspring may be a risk factor for adult schizophrenia.