Deployment of a Reservoir-Targeted Vaccine Against Borrelia burgdorferi Reduces the Prevalence of Babesia microti Coinfection in Ixodes scapularis Ticks.
Deployment of a Reservoir-Targeted Vaccine Against Borrelia burgdorferi Reduces the Prevalence of Babesia microti Coinfection in Ixodes scapularis Ticks.
复制标题
部署针对伯氏疏螺旋体的针对水库的疫苗可降低肩胛硬蜱中巴贝斯虫混合感染的患病率。
DOI：
10.1093/infdis/jiac462
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Gomes-Solecki,Maria
中科院分区：
文献类型：
--
作者：
Vannier,Edouard;Richer,LucianaM;Dinh,DuyM;Brisson,Dustin;Ostfeld,RichardS;Gomes-Solecki,Maria
在美国东北部和中西部北部，微巴贝斯虫和伯氏疏螺旋体以棘球蚴为媒介，白垩鼠为主要宿主。我们之前在一项为期5年的实地试验中证实，一种库靶外表面蛋白a疫苗可降低乙型肝炎的流行。burgdorferi-infected蜱虫。我们获取了试验期间收集的蜱虫和小鼠血液样本，提取了总DNA，并扩增了b。显微18S rnagene。疫苗的部署降低了蜱虫与b病毒合并感染的流行率。感染b型结核菌的小鼠。microti。打破b的地方性循环。伯格氏菌可降低巴贝斯虫病的发病率。
In the Northeast and upper Midwest of the United States,Babesia microtiandBorrelia burgdorferiuseIxodes scapularisticks as vector andPeromyscus leucopusmice as major reservoir host. We previously established, in a 5-year field trial, that a reservoir-targeted outer surface protein A vaccine reduces the prevalence ofB. burgdorferi-infected ticks. We accessed ticks and mouse blood samples collected during the trial, extracted total DNA, and amplified theB. microti 18S rRNAgene. Vaccine deployment reduced the prevalence of ticks coinfected withB. microtiand that of mice infected withB. microti. Breaking the enzootic cycle ofB. burgdorferimay reduce the incidence of babesiosis.