Somatostatin inhibits adrenergic and cholinergic neurotransmission in smooth muscle.
Somatostatin inhibits adrenergic and cholinergic neurotransmission in smooth muscle.
复制标题
生长抑素抑制平滑肌中的肾上腺素能和胆碱能神经传递。
DOI：
10.1016/0024-3205(78)90463-0
复制
发表时间：
1978
期刊：
影响因子：
6.1
通讯作者：
I. H. Slater
中科院分区：
文献类型：
--
作者：
M. Cohen;E. Rosing;K. S. Wiley;I. H. Slater
生长抑素降低豚鼠回肠对场刺激的反应，并减少家兔空肠的自发收缩，这种作用可被河豚毒素阻断。生长抑素也抑制场刺激α肾上腺素能收缩大鼠输精管和兔耳动脉。然而，反应直接应用乙酰胆碱在回肠或去甲肾上腺素在耳动脉或输精管不受生长抑素。这些结果有力地表明，生长抑素抑制平滑肌中胆碱能和肾上腺素能递质物质的神经元释放。
Somatostatin reduced the response to field stimulation in the guinea pig ileum and reduced the spontaneous contractions in the rabbit jejunum, an effect that was blocked by tetrodotoxin. Somatostatin also inhibited field stimulated alpha adrenergic contractions in the rat vas deferens and rabbit ear artery. However, the responses to direct application of either acetylcholine in the ileum or to norepinephrine in the ear artery or vas deferens were not affected by somatostatin. These results strongly suggest that somatostatin inhibits neuronal release of cholinergic and adrenergic transmitter substances in smooth muscle.