Free-Radical Carbo-Alkenylation of Olefins: Scope, Limitations and Mechanistic Insights
Free-Radical Carbo-Alkenylation of Olefins: Scope, Limitations and Mechanistic Insights
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DOI：
10.1002/chem.201605043
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发表时间：
2017-02-01
影响因子：
4.3
通讯作者：
Landais, Yannick
中科院分区：
文献类型：
--
作者：
Beniazza, Redouane;Liautard, Virginie;Landais, Yannick
研究了富电子烯烃的三组分自由基碳烯基化反应，改变了烯烃、自由基前体和最终受体中的取代模式。还制备了新的乙烯基砜，并研究了它们的反应活性。该过程的范围和局限性的建立，并澄清使用选定的二烯作为自由基时钟的反应机理。因此认识到，释放的磺酰基可逆加成到烯烃上是重要的事件，当使用这种多组分碳-烯基化反应时不应忽视。
The three-component free-radical carbo-alkenylation of electron-rich olefins has been studied, varying the substitution pattern in the alkene, in the radical precursor and in the final acceptor. New vinylsulfones were also prepared and their reactivity investigated. The scope and limitations of the process was established, and the reaction mechanism clarified using selected dienes as radical clocks. It was thus recognised that the reversible addition onto the olefin of the released sulfonyl group is an important event, which should not be overlooked when using such multicomponent carbo-alkenylation reactions.