Computational flow dynamics in a geometric model of intussusceptive angiogenesis
Computational flow dynamics in a geometric model of intussusceptive angiogenesis
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DOI：
10.1016/j.mvr.2009.08.004
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发表时间：
2009-12-01
影响因子：
3.1
通讯作者：
Mentzer, Steven J.
中科院分区：
文献类型：
--
作者：
Filipovic, Nenad;Tsuda, Akira;Mentzer, Steven J.
内突性血管生成是通过将单个血管在管腔内分成两个管腔来形成新血管的过程。这种血管生成过程被称为非萌芽或内陷性血管生成，在形态发生和慢性炎症中有描述。由于越来越多的证据表明生理力影响基因转录，机械力与内张性血管生成相关的结构变化有关。为了提供生理剪切应力的空间分布的详细分析，我们开发了一个三维有限元模型的管腔内插柱。基于在成人intuscriptive血管生成中观察到的几何形状，在1至10 μ m的柱尺寸范围内研究了生理剪切应力分布。壁面剪切应力的计算结果表明，腔内柱和侧血管壁上的高剪切应力离散区域具有显著的空间依赖性。此外，内陷柱在柱和血管分叉顶点之间产生了低壁面剪应力的“死区”。我们的结论是，管腔内流场表现出足够的空间分辨率和动态范围，参与intuscrettive血管生成的调节。(C)2009 Elsevier Inc. All rights reserved.
Intussusceptive angiogenesis is a process that forms new blood vessels by the intraluminal division of a single blood vessel into two lumens. Referred to as nonsprouting or intussusceptive angiogenesis, this angiogenic process has been described in morphogenesis and chronic inflammation. Mechanical forces are relevant to the structural changes associated with intussusceptive angiogenesis because of the growing evidence that physiologic forces influence gene transcription. To provide a detailed analysis of the spatial distribution of physiologic shear stresses, we developed a 3D finite element model of the intraluminal intussusceptive pillar. Based on geometries observed in adult intussusceptive angiogenesis, physiologic shear stress distribution was studied at pillar sizes ranging from 1 to 10 mu m. The wall shear stress calculations demonstrated a marked spatial dependence with discrete regions of high shear stress on the intraluminal pillar and lateral vessel wall. Furthermore, the intussusceptive pillar created a "dead zone" of low wall shear stress between the pillar and vessel bifurcation apex. We conclude that the intraluminal flow fields demonstrate sufficient spatial resolution and dynamic range to participate in the regulation of intussusceptive angiogenesis. (C) 2009 Elsevier Inc. All rights reserved.