Zr- and Hf-based nanoscale metal-organic frameworks as contrast agents for computed tomography.
Zr- and Hf-based nanoscale metal-organic frameworks as contrast agents for computed tomography.
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DOI：
10.1039/c2jm32299d
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Dekrafft KE;Boyle WS;Burk LM;Zhou OZ;Lin W
合成并表征了含有高Zr（37wt%）和Hf（57wt%）含量的UiO-66结构的纳米级金属有机框架（NMOFs），并评估了它们作为X射线计算机断层扫描（CT）成像的造影剂的潜力。不同尺寸的Hf-NMOFs用二氧化硅和聚（乙二醇）（PEG）涂覆以增强生物相容性，并用于小鼠的体内CT成像，显示肝脏和脾脏中的衰减增加。
Nanoscale metal-organic frameworks (NMOFs) of the UiO-66 structure containing high Zr (37 wt%) and Hf (57 wt%) content were synthesized and characterized, and their potential as contrast agents for X-ray computed tomography (CT) imaging was evaluated. Hf-NMOFs of different sizes were coated with silica and poly(ethylene glycol) (PEG) to enhance biocompatibility, and were used for in vivo CT imaging of mice, showing increased attenuation in the liver and spleen.