Effects of aflatoxin on the immune system of the chick
Effects of aflatoxin on the immune system of the chick
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黄曲霉毒素对雏鸡免疫系统的影响
DOI：
10.1002/jat.2550090412
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发表时间：
1989
影响因子：
3.3
通讯作者：
D. V. Vadehra
中科院分区：
文献类型：
--
作者：
J. S. Virdi;R. Tiwari;M. Saxena;V. Khanna;G. Singh;S. S. Saini;D. V. Vadehra
用黄曲霉毒素饲料(10%w/w)饲喂3周的雏鸡，法氏囊和胸腺对注射绵羊红细胞的抗体反应降低，体重下降25-38%。免疫器官未见明显的组织病理学改变。抗体滴度从治疗后第6天开始下降，至第15天，抗体滴度在试验鸡体内完全消失。饲喂试验3周后，试验组雏鸡的增重(9.7-37.3%)也低于无毒饲料和水中加白喉沙门氏菌的试验组(108cfu ml−-1)。免疫电泳法研究发现，试验鸡肝匀浆中消失的成分是抗原性的。
A decreased antibody response to injected sheep red blood cells and weight losses to the extent of 25–38% were observed in the bursa Fabricii and thymus in chicks fed an aflatoxin diet (10% w/w) for 3 weeks. The immune organs did not show any significant histopathological changes. The antibody titre decreased from day 6 of treatment onward until the 15th day, when the antibody titre had disappeared completely in the test chicks. The body weight gain was also less in test chicks (9.7–37.3%) given test feed or test feed along with Salmonella pullorum in water (108cfu ml−1) in comparison to chicks given toxin‐free diet and water after 3 weeks of feeding trials. The disappearing component in the test chicks' liver homogenate was found to be antigenic by immunoelectrophoretic studies.