Varying incorporation of fatty acids into phospholipids from muscle, adipose and pancreatic exocrine tissues and thymocytes in adult rats fed with diets rich in different fatty acids
Varying incorporation of fatty acids into phospholipids from muscle, adipose and pancreatic exocrine tissues and thymocytes in adult rats fed with diets rich in different fatty acids
复制标题
饲喂富含不同脂肪酸的饮食的成年大鼠的肌肉、脂肪和胰腺外分泌组织和胸腺细胞中的脂肪酸掺入磷脂的情况不同
DOI：
10.1023/a:1007684808188
复制
发表时间：
2000
影响因子：
13.6
通讯作者：
J. M. Gómez
中科院分区：
文献类型：
--
作者：
F. Soriguer;F. Tinahones;A. Monzon;A. Pareja;G. Rojo;F. Moreno;I. Esteva;J. M. Gómez
尽管进行了大量的研究，但组织或饮食组成在每种脂肪酸的生物分布中可能具有的重要性尚不为人所知。为了确定组织来源和膳食脂肪酸在细胞磷脂脂肪酸组成中的重要性，研究人员给54只雄性成年大鼠喂了一个月的等热量饮食，只改变了它们的脂肪酸组成。6个试验组的脂肪成分分别来源于橄榄油、葵花籽油、鱼油、大豆油、棕榈酸，或82%棕榈酸加18%大豆油，提供必需脂肪酸。用气相色谱法研究了胸腺细胞、胰腺外分泌、肌肉和脂肪组织磷脂的脂肪酸组成。除了棕榈酸（16:0）、二十碳五烯酸（20:5 n-3）和二十二碳六烯酸（22:6 n-3）外，来源组织是细胞磷脂脂肪酸含量比饮食更重要的变异来源。这项研究指出了不同脂肪酸家族之间相互关系的复杂性，以及每个组织对膳食脂肪酸组成变化的特异性，以及从膳食的角度根据双键的位置来划分脂肪酸家族群的不便，因为它们的个体行为，包括饱和脂肪酸，在面对饮食操纵时是非常不同的。该研究还强调了饮食中每一种脂肪酸在每一种组织中的不同行为，在流行病学和实验研究中评估生物效应时应考虑到这一情况。
Despite numerous studies, the importance which the tissue or the composition of the diet may have in the biological distribution of each fatty acid is not well known. To determine the importance of tissue origin and dietary fatty acids in the fatty acid composition of cell phospholipids, 54 male adult rats were fed isocaloric diets for one month varying only in their fatty acid compositions. The fat component of the six experimental groups was derived from olive oil, sunflower oil, fish oil, soybean oil, palmitic acid, or 82% palmitic acid plus 18% soybean oil, supplying the essential fatty acid. The fatty acid composition of phospholipids from thymocytes, pancreatic exocrine, muscle and adipose tissues was studied by gas-chromatography. The tissue of origin was a more important source of variation than diet in the fatty acid content of the cell phospholipids except for palmitic acid (16:0), eicosapentaenoic acid (20:5 n-3), and docosahexaenoic acid (22:6 n-3). This study points out the complexity of the interrelations between different families of fatty acids and of the specificity of each tissue to changes in the composition of dietary fatty acids, as well as the inconvenience of speaking from the dietary point of view of groups of fatty acid families based on the position of the double bond, since their individual behaviour, including saturated fatty acids, is very different in the face of dietary manipulation. The study also highlights the different behaviour of each of the fatty acids in relation to the others in the diet in each of the tissues, a circumstance which should be taken into account when evaluating the biological effects in both epidemiological and experimental studies.
饱和三酰甘油提高仓鼠血浆低密度脂蛋白胆固醇浓度的机制。
DOI：
10.1172/jci114131
发表时间：
1989
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Woollett,LA;Spady,DK;Dietschy,JM
通讯作者：
Dietschy,JM
膳食长链脂肪酸对大鼠不饱和脂肪酸生物合成的影响。
DOI：
10.1093/jn/112.4.619
发表时间：
1982
期刊：
The Journal of nutrition
影响因子：
--
作者：
DeSchrijver,R;Privett,OS
通讯作者：
Privett,OS