Hydrogel, a novel therapeutic and delivery strategy, in the treatment of intrauterine adhesions.
Hydrogel, a novel therapeutic and delivery strategy, in the treatment of intrauterine adhesions.
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DOI：
10.1039/d1tb01005k
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发表时间：
2021-07
期刊：
影响因子：
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通讯作者：
Houyi Lv;Bingbing Wu;Jianyuan Song;Wei Wu;Wangyu Cai;Jian Xu
中科院分区：
文献类型：
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作者：
Houyi Lv;Bingbing Wu;Jianyuan Song;Wei Wu;Wangyu Cai;Jian Xu
宫腔粘连（IUAs）是由子宫内膜下层内膜损伤引起的。它们与子宫内膜修复紊乱有关。近年来，生物活性可控的水凝胶被广泛用于治疗宫内节育器。它们封装雌激素、细胞因子、细胞或外泌体，形成递送系统以释放用于治疗IUAs的治疗组分。此外，作为屏障的水凝胶可以在体内自动降解，降低二次手术引起感染的风险。本文综述了近年来水凝胶作为一种新的替代疗法和人工给药策略在宫内节育器中的应用。
Intrauterine adhesions (IUAs) are caused by damage to the underlying lining of the endometrium. They' re related to disorder of endometrial repair. In recent years, hydrogels with controllable biological activity have been widely used for treating IUAs. They encapsulate estrogen, cytokines, cells, or exosomes, forming a delivery system to release therapeutic components for the treatment of IUAs. In addition, the hydrogel acting as a barrier can be degraded in the body automatically, reducing the risk of infection caused by secondary surgeries. In this review, we summarize the recent progress of hydrogels and their application in IUAs as both a novel alternative therapeutic and an artificial delivery strategy.