A combined DTI and resting state functional MRI study in patients with postherpetic neuralgia
A combined DTI and resting state functional MRI study in patients with postherpetic neuralgia
复制标题
带状疱疹后神经痛患者的 DTI 和静息态功能 MRI 联合研究
DOI：
10.1007/s11604-020-00926-4
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发表时间：
2020-02-18
影响因子：
2.1
通讯作者：
Li, Yonggang
中科院分区：
文献类型：
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作者：
Dai, Hui;Jiang, Chengcheng;Li, Yonggang
目的探讨带状疱疹后遗神经痛（PHN）患者脑组织超微结构和功能的变化。采用3 T MR扫描机进行弥散张量成像（DTI）和静息态功能MRI（rfMRI）扫描。部分各向异性（FA）和平均扩散率（MD）的t-图后，DTI数据处理。低频波动（ALFF）和分数ALFF（fALFF）的振幅后的rfMRI数据处理。采用双样本检验比较PHN患者与健康对照组的FA、MD、ALFF和fALFF差异。结果两组在性别、年龄和受教育年限等参数上均无显著差异。FA、MD、ALFF和（或）fALFF显示了特定疼痛或疼痛相关脑区的显著改变，如脑干、小脑、顶叶、楔前叶、额叶、颞叶、中央后回和中央前回、胼胝体、扣带回、壳核和海马等。结论慢性疼痛、感觉辨别、情绪和认知等脑区自发活动的多局部改变可能形成一个网络，提示PHN的中枢机制复杂。脑组织结构和功能的共同作用可能在理解PHN致痛的神经机制中起关键作用。
PurposeTo explore the brain microstructural and functional changes in patients with postherpetic neuralgia (PHN).Materials and methods12 PHN patients and 12 healthy volunteers were enrolled. Diffusion tensor imaging (DTI) and resting-state functional MRI (rfMRI) sequences were scanned by a 3T MR scanner. Fractional anisotropy (FA) and mean diffusivity (MD) t-maps were obtained following DTI data processing. The amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were obtained following rfMRI data processing. A two samplet-test was performed to compare the FA, MD, ALFF and fALFF differences between the PHN patients and healthy controls.ResultsNo significant differences were noted with regard to the parameters gender, age and education years between the two groups. FA, MD, ALFF and/or fALFF indicated significant alterations in specific pain or pain-related brain regions, such as brainstem, cerebellum, parietal lobe, precuneus, frontal lobe, temporal lobe, postcentral and precentral gyrus, corpus callosum, cingulate gyrus, putamen and insula.ConclusionMulti-local alterations of spontaneous brain activity could form a network related to chronic pain, sensory discrimination, emotion and cognition, suggesting complicated central mechanisms of PHN. The combined-action of brain microstructure and function may play a critical role in comprehension of neurological mechanisms of PHN-induced pain.