Low incidence of estrogen receptor in breast carcinomas with rapid rates of cellular replication
Low incidence of estrogen receptor in breast carcinomas with rapid rates of cellular replication
复制标题
乳腺癌中雌激素受体的发生率低且细胞复制速度快
作者：
MD JOHN S. MEYER;PHD' B. RAMANATH RAO;Phd SUE C. STEVENS;BS WILMA L. WHITE;Harold Briggs;M. Thomas Cantley;Rhoda Facher;JoAnne Stuerman;N. V. Dillen;B. Barbara Hixon
本文分析了63例原发性乳腺浸润性癌细胞浆雌激素受体（ER）和胸苷标记指数（TLI）的测定结果。通过使用葡聚糖-活性炭吸附胞质溶胶中未结合的氚化雌二醇-17/β（E2）进行ER测定。TLI测量为每百个由氚化胸苷标记的肿瘤细胞核的数目。低TLI与ER的存在有显著的相关性，而TLI < 2.5的19个肿瘤在原发灶或腋窝转移灶中均含有ER，TLI在2.5 - 10的30个肿瘤中有25个含有ER，而TLI > 10的14个肿瘤中只有4个含有ER（p < 0.001）。TLI和E2的饱和结合显著负相关（r =-0.436，p < 0.001）。它的结论是，乳腺癌的去分化与高TLI和ER的情况下，并建议与最快速的增殖率的癌将包括最高比例的肿瘤激素治疗无反应。
The results of assay for estrogen receptor (ER) in the tumor cytosol and thymidine labeling indices (TLI) of 63 primary invasive carcinomas of the breast were analyzed. The ER assay was performed by using dextran‐charcoal to adsorb unbound tritiated estradiol‐17/β (E2) in the cytosol. The TLI was measured as the number per hundred of neoplastic cell nuclei labeled by tritiated thymidine. A significant association between low TLI and presence of ER was found. Whereas all 19 tumors with TLI < 2.5 contained ER in the primary lesion or in axillary metastases and ER was found in 25 of 30 tumors with TLI between 2.5 and 10, only 4 of 14 tumors with TLI > 10 contained ER (p < 0.001). TLI and saturable binding of E2 were significantly negatively correlated (r = ‐0.436, p < 0.001). It is concluded that dedifferentiation in breast carcinomas is associated with both high TLI and absence of ER, and suggested that the carcinomas with the most rapid proliferative rates will include the highest proportion of tumors unresponsive to hormonal therapy.