An updated hip fracture incidence rate for Brazil: the Brazilian Validation Osteoporosis Study (BRAVOS)
An updated hip fracture incidence rate for Brazil: the Brazilian Validation Osteoporosis Study (BRAVOS)
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DOI：
10.1007/s11657-022-01127-4
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发表时间：
2022-12-01
影响因子：
3
通讯作者：
Lazaretti-Castro, Marise
中科院分区：
文献类型：
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作者：
Albergaria, Ben-Hur;Zerbini, Cristiano A. F.;Lazaretti-Castro, Marise
首次评估了2年（2010-2012年）期间巴西三个代表性地理区域的髋部骨折发生率。估计的发病率因地区而异，与以前报告的发病率明显不同。因此，国家指南以及FRAX巴西应根据这一新的data.Purpose修订，以确定每年的发病率髋部骨折的个人年龄在50岁及以上，生活在3个城市位于不同地区的国家。研究骨折发生率的年龄、性别和地区差异。根据所获得的数据，估计全国发病率的髋部骨折引起的骨质疏松症，以改善预防strategies.Methods回顾性，观察性研究，包括所有患者年龄>= 50岁，因为髋部骨折在三个城市（贝伦，Joinville和维托里亚）从2010年至2012年在巴西的代表性地理区域的医院。数据来自这些城市的医疗记录。我们分析发病率（粗和年龄和性别标准化率）为髋部fracture.Results有1025（310男性和715女性）髋部骨折的50岁以上合并人群从三个城市。髋部骨折的粗发生率为103.3/100，000（95%置信区间[CI= 97.0; 109.7]），男性为77.4/100，000（95% CI= 68.8; 86.0），女性为125.2/100，000（95% CI =116.0; 134.4）。按年龄和性别标准化的发病率为105.9例/100，000人/年（95% CI= 99.4; 112.4）;男性为78.5例/100，000人/年（95% CI =69.8; 87.3），女性为130.6例/100，000人/年（95% CI= 121.0，140.2）。位于赤道地区（南纬1度27分）的贝伦，其粗发病率和年龄调整发病率显著低于Joinville（南纬26度18分）和维托里亚（南纬20度19分），这两个地区之间没有差异。骨折的发病率呈指数增长，随着年龄的增长，和妇女的骨折的风险约为两倍，比男性。结论髋部骨折主要影响老年妇女，并提出了很大的变化，在巴西的不同地区之间的发病率。巴西髋部骨折的发病率与以前报道的有明显不同，因此，巴西的国家指南和FRAX模型应予以修订。
A Summary Hip fracture incidence rates in three representative geographic areas in Brazil over a period of 2 years (2010-2012) were assessed for the first time. Estimated incidence rates varied regionally, and markedly differed from those previously reported. Thus, national guidelines as well as FRAX Brazil should be revised in light of this new data.Purpose To determine the annual incidence of hip fractures in individuals aged 50 years and over, living in 3 cities located in different regions of the country. To investigate the age, gender, and regional differences in fracture rates. Based on the obtained data, to estimate the national incidence of hip fractures resulting from osteoporosis, in order to improve prevention strategies.Methods Retrospective, observational study including all patients aged >= 50 years admitted in hospitals because of a hip fracture in three cities (Belem, Joinville, and Vitoria) from representative geographic areas in Brazil from 2010 to 2012. Data were obtained from medical records in those cities. We analyzed incidence rates (crude and age- and gender-standardized rates) for hip fractures.Results There were 1025 (310 in men and 715 in women) hip fractures in the over 50-year-old merged population from the three cities. The crude incidence rate for hip fracture was 103.3/100,000 (95% confidence interval [CI= 97.0; 109.7), in men 77.4/100,000 (95% CI= 68.8; 86.0), and in women 125.2/100,000 (95% CI =116.0; 134.4). Incidence standardized for age and gender was 105.9 cases per 100,000 persons per year (95% CI= 99.4; 112.4); 78.5 cases per 100,000 (95% CI =69.8; 87.3) in men and 130.6 cases 100,000 in women (95% CI= 121.0, 140.2) per year. Belem, located in the equatorial region (latitude 1 degrees 27' S), had significantly lower crude and age-adjusted incidence than Joinville (latitude 26 degrees 18' S) and Vitoria (latitude 20 degrees 19' S), which were no different from each other. The incidence of fractures increased exponentially with age, and women had about twice the risk of fractures than men.Conclusions Hip fracture mainly affects elderly women and presents great variability in incidence between the different regions in Brazil. The incidence of hip fractures in Brazil differed markedly from that reported previously, so that national guidelines and the FRAX model for Brazil should be revised.