Biological determinants of bladder cancer gene expression subtypes.
Biological determinants of bladder cancer gene expression subtypes.
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DOI：
10.1038/srep10957
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发表时间：
2015-06-08
影响因子：
4.6
通讯作者：
Höglund M
中科院分区：
文献类型：
--
作者：
Aine M;Eriksson P;Liedberg F;Sjödahl G;Höglund M
通过基因表达谱对肿瘤进行分子分层已被应用于大量的人类恶性肿瘤，并为个性化治疗带来了巨大的希望。尿路上皮癌的综合分类方案已经由三个独立的小组提出，但以前没有同时在独立的数据进行评估。在这里，我们映射到一个丰富的独立的数据集的内在结构上的拟议的分子亚型之间的相互关系，并显示在每个方案内的亚型分层可以解释在一组共同的基本生物过程。我们强调了尿路上皮癌分子亚型的新的生物学和基因组驱动因素，并表明携带不同分子途径的基因组畸变特征的肿瘤会聚在一个共同的顶级表型上，对应于非肌肉浸润性疾病的两个主要分子亚型。
Molecular stratification of tumors by gene expression profiling has been applied to a large number of human malignancies and holds great promise for personalized treatment. Comprehensive classification schemes for urothelial carcinoma have been proposed by three separate groups but have not previously been evaluated simultaneously in independent data. Here we map the interrelations between the proposed molecular subtypes onto the intrinsic structure of a rich independent dataset and show that subtype stratification within each scheme can be explained in terms of a set of common underlying biological processes. We highlight novel biological and genomic drivers of urothelial carcinoma molecular subtypes and show that tumors carrying genomic aberrations characteristic of distinct molecular pathways converge on a common top level phenotype corresponding to the two major molecular subtypes of non-muscle invasive disease.