CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma
CIAPIN1 inhibits the growth and proliferation of clear cell renal cell carcinoma
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CIAPIN1 抑制透明细胞肾细胞癌的生长和增殖。
DOI：
10.1016/j.canlet.2008.10.044
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发表时间：
2009-04-08
期刊：
影响因子：
9.7
通讯作者：
Fan, Daiming
中科院分区：
文献类型：
--
作者：
He, Lijie;Wang, Hanmin;Fan, Daiming
我们以前的研究表明，CIAPIN1基因缺失与人胃癌的发生有直接关系。本文报告102例肾透明细胞癌(CcRCC)组织中CIAPIN1表达缺失或明显降低(P<；0.05)。腺病毒载体上调CIAPIN1在体内外对肾细胞癌来源的细胞生长有明显的抑制作用，并使细胞周期停滞于G1期。同时，CIAPIN1诱导的生长抑制部分调节多种蛋白的表达，包括抑制细胞周期蛋白D1、细胞周期蛋白E、CDK2、CDK4、p-Rb和VEGF，但上调p27(Kip1)和Rb。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
Our previous studies indicated a direct correlation with loss of CIAPIN1 and carcinogenesis of tumor in human gastric cancer. Here we presented that the expression of CIAPIN1 was absent or significantly decreased in 102 cases of clear cell renal cell carcinoma (CCRCC) tissues (P < 0.05). Up-regulating CIAPIN1 by adenoviral vectors exhibited significant inhibition of CCRCC-derived cell growth in vitro and in vivo with G1 cell cycle arrest. Simultaneously, CIAPIN1-induced growth suppression was found partially to regulate various proteins, including inhibition of cyclinD1, cyclinE, cdk2, cdk4, p-Rb and VEGF, but upregulation of p27(Kip1) and Rb. (C) 2008 Elsevier Ireland Ltd. All rights reserved.