PATHOLOGICAL-CHANGES IN THE NUCLEUS OF MEYNERT IN ALZHEIMERS AND PARKINSONS DISEASES
PATHOLOGICAL-CHANGES IN THE NUCLEUS OF MEYNERT IN ALZHEIMERS AND PARKINSONS DISEASES
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DOI：
10.1016/0022-510x(83)90045-x
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发表时间：
1983-01-01
影响因子：
4.4
通讯作者：
TOMLINSON, BE
中科院分区：
文献类型：
--
作者：
CANDY, JM;PERRY, RH;TOMLINSON, BE
老年痴呆症（SDAT） Meynert核的神经病理学和神经化学综合评估表明，胆碱能生化活性，胆碱乙酰转移酶，在核中更广泛地降低（> 90%），而不是推定的胆碱能核周的损失（35%）。乙酰胆碱酯酶组织化学活性在核内的单个神经元中基本保留，而在SDAT中新皮层中几乎没有。这些异常与突出到皮层的胆碱能轴突的原发性变性和皮层下核周围的继发性丧失相一致。对帕金森病病例的初步观察表明，该病中Meynert核的神经元丢失可能比SDAT更严重，并且先前的研究并未一致证明帕金森病中皮质胆碱乙酰转移酶活性降低。这些观察结果，以及SDAT和帕金森病（分别为神经原纤维缠结和路易体形成）中核神经病理学的主要差异表明，胆碱能系统在两种疾病过程中的参与可能不同。
Combined neuropathological and neurochemical assessment of the nucleus of Meynert in senile dementia of Alzheimer type (SDAT) have demonstrated that the cholinergic biochemical activity, choline acetyltransferase, is more extensively reduced in the nucleus (> 90%) than the loss of putative cholinergic perikarya (35%). Acetylcholinesterase histochemical activity was substantially retained in individual neurons in the nucleus although virtually absent from the neocortex in SDAT. These abnormalities are consistent with a primary degeneration of cholinergic axons projecting to the cortex and secondary loss of perikarya from the subcortical nucleus. Preliminary observations on cases of Parkinson''s disease suggest that the neuronal loss from the nucleus of Meynert may be greater in this disease than in SDAT, and previous studies have not consistently demonstrated a reduction in cortical choline acetyltransferase activities in Parkinson''s disease. These observations, together with major differences in the neuropathology of the nucleus in SDAT and Parkinson''s disease (neurofibrillary tangle and Lewy body formation, respectively) suggest that the involvement of the cholinergic system may differ in the 2 disease processes.